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Key Documents

P1306

Sigma-Aldrich

Peptide YY human

≥97% (HPLC), synthetic

Synonym(s):

PYY, Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2

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About This Item

Empirical Formula (Hill Notation):
C194H295N55O57
CAS Number:
118997-30-1
Molecular Weight:
4309.75
MDL number:
MFCD00081843
UNSPSC Code:
51111800
NACRES:
NA.32

biological source

synthetic

Quality Level

200

Assay

≥97% (HPLC)

form

solid

UniProt accession no.

P10082

storage temp.

−20°C

Gene Information

human ... PYY(5697)

Amino Acid Sequence

Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2

General description

Human peptide YY (PYY) is secreted by mucosal L cells in the distal ileum, colon and rectum. It consists of 36 amino acids. The gene encoding PYY is localized on human chromosome 17q21.1.

Application

Peptide YY human has been used as a supplement in Roswell Park Memorial Institute medium (RPMI medium) to culture pancreatic duct-derived cells.

Biochem/physiol Actions

Gut hormone that inhibits both secretin and cholecystokinin-stimulated pancreatic secretion. Endogenous nonselective agonist at NPY receptors.
Human peptide YY (PYY) has a role in food ingestion, gut motility and insulin secretion. The protein suppresses appetite. It has been associated with obesity and type 2 diabetes. PYY also has a role in energy homeostasis.

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Rapid and Efficient In Vitro Generation of Pancreatic Islet
Progenitor Cells from Nonendocrine Epithelial Cells in the
Adult Human Pancreas
JOSEPHINE S. D?ALESSANDRO
Stem Cells and Development (2007)
TLR ligands and butyrate increase Pyy expression through two distinct but inter-regulated pathways.
Larraufie P
Cellular Microbiology (2017)
The Association of Serum Total Peptide YY (PYY) with Obesity and Body Fat Measures in the CODING Study.
Cahill F
PLoS ONE (2014)
Genomic and gene expression signature of the pre-invasive
testicular carcinoma in situ
Kristian Almstrup
Cell and Tissue Research (2005)
Expression of peptide YY by human blood leukocytes.
Holler JP
Peptides (2014)
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