- Ageing and chronic intermittent hypoxia mimicking sleep apnea do not modify local brain tissue stiffness in healthy mice.
Ageing and chronic intermittent hypoxia mimicking sleep apnea do not modify local brain tissue stiffness in healthy mice.
Journal of the mechanical behavior of biomedical materials (2017-03-13)
Ignasi Jorba, Maria José Menal, Marta Torres, David Gozal, Gerard Piñol-Ripoll, Anna Colell, Josep M Montserrat, Daniel Navajas, Ramon Farré, Isaac Almendros
PMID28284842
RESUMO
Recent evidence suggests that obstructive sleep apnea (OSA) may increase the risk of Alzheimer´s disease (AD), with the latter promoting alterations in brain tissue stiffness, a feature of ageing. Here, we assessed the effects of age and intermittent hypoxia (IH) on brain tissue stiffness in a mouse model of OSA. Two-month-old and 18-month-old mice (N=10 each) were subjected to IH (20% O
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Krebs-Henseleit Buffer Modified, With 2000 mg/L glucose, without calcium chloride and sodium bicarbonate, powder, suitable for cell culture