A novel coumarin-type derivatizing reagent of alcohols: application in the CD exciton chirality method for microscale structural determination

[reaction: see text] Imidazolide 1 has been prepared from 7-diethylaminocoumarin-3-carboxylic acid (2) and 1,1'-carbonyldiimidazole. This novel fluorescent derivatization reagent can be used in CD exciton chirality method for microscale structural determinations of hydroxyl-containing compounds. It features a red-shifted chromophore and offers the advantages of fluorescence and high sensitivity.