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  • Synthesis and SAR of GlyT1 inhibitors derived from a series of N-((4-(morpholine-4-carbonyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamides.

Synthesis and SAR of GlyT1 inhibitors derived from a series of N-((4-(morpholine-4-carbonyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamides.

Bioorganic & medicinal chemistry letters (2006-09-22)
Zhijian Zhao, Julie A O'Brien, Wei Lemaire, David L Williams, Marlene A Jacobson, Cyrille Sur, Doug J Pettibone, Philip R Tiller, Sheri Smith, George D Hartman, Scott E Wolkenberg, Craig W Lindsley
PMID16987662
RESUMO

This Letter describes the synthesis and SAR, developed through an iterative analog library approach, of potent and selective non-sarcosine-derived GlyT1 inhibitors.