- Rational design of a Tn antigen mimic.
Rational design of a Tn antigen mimic.
Chemical communications (Cambridge, England) (2011-04-01)
Francisco Corzana, Jesús H Busto, Filipa Marcelo, Marisa García de Luis, Juan L Asensio, Sonsoles Martín-Santamaría, Yolanda Sáenz, Carmen Torres, Jesús Jiménez-Barbero, Alberto Avenoza, Jesús M Peregrina
PMID21451866
RESUMO
A novel Tn antigen mimic, in which the natural underlying amino acid has been replaced by the non-natural α-methylserine analogue, is reported. This derivative exhibits a similar affinity for a natural lectin as for the natural Tn and retains the bioactive conformation observed in the Tn-containing glycopeptides with anti-MUC1 antibodies.