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Merck
  • Sustained viral response in a hepatitis C virus-infected chimpanzee via a combination of direct-acting antiviral agents.

Sustained viral response in a hepatitis C virus-infected chimpanzee via a combination of direct-acting antiviral agents.

Antimicrobial agents and chemotherapy (2010-12-01)
David B Olsen, Mary-Ellen Davies, Larry Handt, Kenneth Koeplinger, Nanyan Rena Zhang, Steven W Ludmerer, Donald Graham, Nigel Liverton, Malcolm MacCoss, Daria Hazuda, Steven S Carroll
RESUMO

Efforts to develop novel, interferon-sparing therapies for treatment of chronic hepatitis C (HCV) infection are contingent on the ability of combination therapies consisting of direct antiviral inhibitors to achieve a sustained virologic response. This work demonstrates a proof of concept that coadministration of the nucleoside analogue MK-0608 with the protease inhibitor MK-7009, both of which produced robust viral load declines as monotherapy, to an HCV-infected chimpanzee can achieve a cure of infection.

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Sigma-Aldrich
Tubercidin, from Streptomyces tubercidicus, ~95%