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Merck

Regioselective multi-component synthesis of 1H-pyrazolo[3,4-d]pyrimidine-6(7H)-thiones.

Molecular diversity (2012-08-29)
Shirin Safaei, Iraj Mohammadpoor-Baltork, Ahmad Reza Khosropour, Majid Moghadam, Shahram Tangestaninejad, Valiollah Mirkhani
RESUMO

A variety of pyrazolo[3,4-d]pyrimidine-6(7H)-thione derivatives were easily synthesized with a novel, simple, efficient, and regioselective method via three-component condensation reaction of 5-methyl-1H-pyrazol-3-amine, arylisothiocyanates, and aldehydes in the presence of catalytic amount of p-toluenesulfonic acid (p-TSA) in 1-butyl-3-methylimidazolium bromide ionic liquid with excellent yields and short reaction times.

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Sigma-Aldrich
Sodium p-toluenesulfinate, 95%
Sigma-Aldrich
Sodium p-toluenesulfinate, purum, anhydrous, ≥96.0% (NT)