Highly regioselective Au(I)-catalyzed hydroamination of ynamides and propiolic acid derivatives with anilines.

A highly regioselective hydroamination of unsymmetrical electron-poor and electron-rich alkynes with anilines catalyzed by Au(I) under mild conditions is reported. In addition, applications toward indole syntheses are presented including an example of a one-pot synthesis from a nonfunctionalized aniline.