Synthesis of zwitterionic hydrophilic magnetic mesoporous silica materials for endogenous glycopeptide analysis in human saliva.

A novel zwitterionic hydrophilic magnetic mesoporous silica was prepared for endogenous glycopeptide enrichment prior to MS analysis. For the first time, the material was successfully applied in capturing endogenous glycopeptides from human saliva, indicating great potential of this strategy for glycopeptidome analysis.