- A novel Bcl-XL inhibitor Z36 that induces autophagic cell death in Hela cells.
A novel Bcl-XL inhibitor Z36 that induces autophagic cell death in Hela cells.
Autophagy (2009-02-27)
Jian Lin, Zhibin Zheng, Yanjun Li, Wenyu Yu, Wu Zhong, Songhai Tian, Fang Zhao, Xiaobai Ren, Junhai Xiao, Nan Wang, Siyang Liu, Lili Wang, Fugeng Sheng, Yingyu Chen, Changwen Jin, Song Li, Bin Xia
PMID19242113
RESUMO
Inhibition of Bcl2 family proteins Bcl-X(L) and Bcl-2 represents a promising drug development strategy for cancer treatment by triggering apoptosis in cancer cells. Here we report a novel Bcl-X(L) inhibitor, Z36, which unexpectedly induces only autophagic cell death, but not apoptosis. This special property distinguishes Z36 from other previously reported Bcl-X(L) and Bcl-2 inhibitors that induce cancer cell death mainly through apoptosis, and makes Z36 an attractive molecular tool for studying the cellular regulation of autophagic cell death and apoptosis.
MATERIAIS