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LO4100

Sigma-Aldrich

LOPAC®1280 - Pequena escala

Sinônimo(s):

Biblioteca de compostos farmacologicamente ativos - pequena escala

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About This Item

Número CE:
200-664-3
Código UNSPSC:
12352200
NACRES:
NA.77

forma

liquid

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

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Descrição geral

Compounds are arranged in 96-well format in 16 racks of 80, one compound per well (25 μl at 10 mM in DMSO in archival storage racks).
LOPAC® 1280 is an extensively used library of pharmacologically active compounds. This library includes 1,280 marketed drugs, failed development candidates, and small molecules with well-characterized activities. LOPAC 1280 spans a broad molecular weight range, exhibits multiple mechanisms of action and interacts with a variety of biological receptors.

Aplicação

LOPAC® 1280 - Small Scale has been used:
  • in sprouting assay to screen potential lymphangiogenic inhibitors and the signaling pathways involved in lymphangiogenesis
  • for identification of neuroactive compounds by measuring spontaneous activity within single zebrafish embryos by high-content screening assay
  • for high-throughput Screen for ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1; also known as CD39) and ecto-5′-nucleotidase (CD73) inhibitors

Características e benefícios

Arquivo SDFile fornecido para montar um banco de dados com:
  • Estrutura
  • Nome primário
  • Nome secundário
  • Atividade farmacológica
  • Número do produto
  • Posição na estante
Inclui as moléculas semelhantes a medicamentos mais modernas nos campos de sinalização celular e neurociência:

  • Apoptose
  • Proteínas G e nucleotídeos cíclicos
  • Regulação e expressão gênica
  • Canais iônicos
  • Sinalização de lipídios
  • Resistência a múltiplos medicamentos
  • Neurotransmissão
  • Fosforilação

Outras notas

For sale inside of the U.S. only. Customers outside the US should refer to Product Code LO4200.

Informações legais

LOPAC is a registered trademark of Merck KGaA, Darmstadt, Germany

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Lact. - Muta. 1B - Repr. 1A - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT RE 2 - STOT SE 2

Código de classe de armazenamento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Ponto de fulgor (°F)

188.6 °F

Ponto de fulgor (°C)

87 °C

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Sara M Vliet et al.
Toxicology and applied pharmacology, 329, 241-248 (2017-06-18)
Spontaneous activity represents an early, primitive form of motor activity within zebrafish embryos, providing a potential readout for identification of neuroactive compounds. However, despite use as an endpoint in chemical screens around the world, the predictive power and limitations of
Roland E Kälin et al.
Blood, 114(5), 1110-1122 (2009-05-30)
Angiogenesis and lymphangiogenesis are essential for organogenesis but also play important roles in tissue regeneration, chronic inflammation, and tumor progression. Here we applied in vivo forward chemical genetics to identify novel compounds and biologic mechanisms involved in (lymph)angiogenesis in Xenopus
Meera Kumar et al.
SLAS discovery : advancing life sciences R & D, 25(3), 320-326 (2019-12-24)
Production of adenosine in the extracellular tumor microenvironment elicits strong immunosuppression and is associated with tumor progression. Thus, targeting adenosine-generating ectonucleotidases is a potential strategy to stimulate and prolong antitumor immunity. Because the reaction products of ectonucleotidases differ by a
Martin Michael Peter Schulz et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(40), E2665-E2674 (2012-09-06)
Lymphangiogenesis plays an important role in promoting cancer metastasis to sentinel lymph nodes and beyond and also promotes organ transplant rejection. We used human lymphatic endothelial cells to establish a reliable three-dimensional lymphangiogenic sprouting assay with automated image acquisition and
Miao Xu et al.
Nature medicine, 22(10), 1101-1107 (2016-08-30)
In response to the current global health emergency posed by the Zika virus (ZIKV) outbreak and its link to microcephaly and other neurological conditions, we performed a drug repurposing screen of ∼6,000 compounds that included approved drugs, clinical trial drug
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Artigos

LOPAC®1280 Small Molecules Screening

Explore compound library screening options with our Pharmacologically Active Compounds portfolio.

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