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LO4100

LOPAC®1280 - Pequena escala

Sinônimo(s):

Biblioteca de compostos farmacologicamente ativos - pequena escala

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Sobre este item

UNSPSC Code:
12352200
EC Number:
200-664-3
NACRES:
NA.77
Form:
liquid
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form

liquid

Quality Segment

drug control

Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet

shipped in

dry ice

storage temp.

−20°C

General description

LOPAC® 1280 is an extensively used library of pharmacologically active compounds. This library includes 1,280 marketed drugs, failed development candidates, and small molecules with well-characterized activities. LOPAC 1280 spans a broad molecular weight range, exhibits multiple mechanisms of action and interacts with a variety of biological receptors.
Compounds are arranged in 96-well format in 16 racks of 80, one compound per well (25 μl at 10 mM in DMSO in archival storage racks).

Application

LOPAC® 1280 - Small Scale has been used:
  • in sprouting assay to screen potential lymphangiogenic inhibitors and the signaling pathways involved in lymphangiogenesis
  • for identification of neuroactive compounds by measuring spontaneous activity within single zebrafish embryos by high-content screening assay
  • for high-throughput Screen for ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1; also known as CD39) and ecto-5′-nucleotidase (CD73) inhibitors

Features and Benefits

Arquivo SDFile fornecido para montar um banco de dados com:
  • Estrutura
  • Nome primário
  • Nome secundário
  • Atividade farmacológica
  • Número do produto
  • Posição na estante
Inclui as moléculas semelhantes a medicamentos mais modernas nos campos de sinalização celular e neurociência:

  • Apoptose
  • Proteínas G e nucleotídeos cíclicos
  • Regulação e expressão gênica
  • Canais iônicos
  • Sinalização de lipídios
  • Resistência a múltiplos medicamentos
  • Neurotransmissão
  • Fosforilação

Other Notes

For sale inside of the U.S. only. Customers outside the US should refer to Product Code LO4200.

Legal Information

LOPAC is a registered trademark of Merck KGaA, Darmstadt, Germany

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Palavra de aviso

Danger

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Lact. - Muta. 1B - Repr. 1A - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT RE 2 - STOT SE 2

Classe de armazenamento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Ponto de inflamação (°F)

188.6 °F

Ponto de inflamação (°C)

87 °C

O que está acontecendo?

WGK 3

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Certificados de análise (COA)

Lot/Batch Number

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Questions

1–9 of 9 Questions  

  1. Where can I find preparation instruction, storage and stability of the LOPAC 1280 - Small Scale Products LO4100 and LO4200?

    1 answer

    1. The information is available in the datasheet of a similar product LO1280.

      Helpful?

  2. Are the LOPAC 1280 - Small Scale Products LO4100 and LO4200  US approved?

    1 answer

    1. About 30% of the collection is made up of drugs approved for use in the US.

      Helpful?

  3. Are the LOPAC 1280 - Small Scale Products LO4100 and LO4200 approved for therapeutic use?

    1 answer

    1. Although there are FDA approved drugs in the set, we market them based on their research application and not necessarily their therapeutic indications. All of the information we have is included on the CD that is received with the library. We do not include information from the Physician's Desk Reference.

      Helpful?

  4. Can I get a list of CAS numbers of the drugs sent with LOPAC 1280 - Small Scale Products LO4100 and LO4200?

    1 answer

    1. There is no CAS number list available.

      Helpful?

  5. What is the difference between the LOPAC®,1280 product numbers LO4100 and LO1280?

    1 answer

    1. The compound per well in LO4100 is 25 ul at 10mM in DMSO versus 250 ul in the product LO1280

      Helpful?

  6. What is the difference between the LOPAC1280 Products LO4100 and LO4200?

    1 answer

    1. These 2 products are the same. LO4100 is the US version versus LO4200 is the International version.

      Helpful?

  7. Is the LOPAC 1280 - Small Scale Products LO4100 and LO4200 CD shipped with the product?

    1 answer

    1. Yes, the CD is shipped with the product. If you do not receive it you should contact Sigma-Aldrich Technical Services at techserv@sial.com or 1800-325-5832.

      Helpful?

  8. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  9. What is on the LOPAC 1280 - Small Scale Products LO4100 and LO4200 CD?

    1 answer

    1. The CD contains the SDFile - provided to construct a database containing structure, primary name, secondary, Pharmacological Activity. Product number and Rack position.

      Helpful?

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