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36799

Sigma-Aldrich

7-(Diethylamino)coumarin-3-carboxylic acid

BioReagent, suitable for fluorescence, ≥98.0% (HPCE)

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About This Item

Fórmula empírica (Notação de Hill):
C14H15NO4
Número CAS:
50995-74-9
Peso molecular:
261.27
Beilstein:
6145963
Número MDL:
MFCD00068721
Código UNSPSC:
12352106
ID de substância PubChem:
57649663
NACRES:
NA.32

linha de produto

BioReagent

Ensaio

≥98.0% (HPCE)

pf

222-224 °C (dec.) (lit.)

solubilidade

DMF: soluble
DMSO: soluble

fluorescência

λex 409 nm; λem 473 nm in 0.1 M Tris pH 9.0

adequação

suitable for fluorescence

cadeia de caracteres SMILES

CCN(CC)c1ccc2C=C(C(O)=O)C(=O)Oc2c1

InChI

1S/C14H15NO4/c1-3-15(4-2)10-6-5-9-7-11(13(16)17)14(18)19-12(9)8-10/h5-8H,3-4H2,1-2H3,(H,16,17)

chave InChI

WHCPTFFIERCDSB-UHFFFAOYSA-N

Aplicação

7-(Diethylamino)coumarin-3-carboxylic acid (7-DCCA) may be used to study its photophysical properties in various solvents and solvent mixtures and as a fluorescent label for amine modification and protein conjugation

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Outras notas

Fluorescent label for amine modification and protein conjugation

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Sigma-Aldrich

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Atsuko Kakio et al.
Biochemistry, 41(23), 7385-7390 (2002-06-05)
GM1 ganglioside-bound amyloid beta-protein (GM1-Abeta), found in brains exhibiting early pathological changes of Alzheimer's disease (AD) plaques, has been suggested to accelerate amyloid fibril formation by acting as a seed. We have previously found using dye-labeled Abeta that Abeta recognizes
The photophysics of 7-(N,N'-diethylamino)coumarin-3-carboxylic acid in water/AOT/isooctane reverse micelles: an excitation wavelength dependent study.
Chatterjee A, Maity B, Seth D.
Physical Chemistry Chemical Physics, 1894-1906 (2012)
Keisuke Ikeda et al.
FEBS letters, 580(28-29), 6587-6595 (2006-11-28)
The formation of fibrils by amyloid beta-protein (Abeta) is considered as a key step in the pathology of Alzheimer's disease (AD). Inhibiting the aggregation of Abeta is a promising approach for AD therapy. In this study, we used biocompatible nanogels
Tiffany P Gustafson et al.
Chemical communications (Cambridge, England), 49(7), 680-682 (2012-12-12)
Nanothermometers composed from a gold nanorod core, temperature sensitive linker and fluorescent dye are reported. The nanothermometers have low fluorescence due to a self-quenching mechanism at temperatures below 50 °C and become highly fluorescence above 70 °C.
Rosaria Notariale et al.
Acta biochimica Polonica, 65(4), 585-594 (2018-11-18)
The major acid-soluble protein components of the mussel Mytilus galloprovincialis sperm chromatin consist of the protamine-like proteins PL-II, PL-III and PL-IV, an intermediate group of sperm nuclear basic proteins between histones and protamines. The aim of this study was to
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