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Merck

IDE

insulin-degrading enzyme

Sinônimos:
INSULYSIN
Espécies:
ID UniProtKB:
ID do gene:
  • Human(3416) Summary: This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]
  • Mouse(15925) insulin degrading enzyme
  • Rat(25700) insulin degrading enzyme
  • fruit fly(40248) Insulin degrading metalloproteinase
  • Zebrafish(561390) insulin-degrading enzyme
  • dog(477768) insulin-degrading enzyme
  • chicken(423814) insulin-degrading enzyme
  • sheep(101104194) insulin-degrading enzyme
  • cow(523752) insulin-degrading enzyme
  • Horse(100071303) insulin-degrading enzyme
  • domestic cat(101093646) insulin-degrading enzyme
  • naked mole-rat(101706921) insulin-degrading enzyme
  • domestic guinea pig(100719651) insulin-degrading enzyme

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Antibodies

Número do produto
Descrição
Reatividade de espécies
Aplicação
Anti-Insulin-degrading enzyme (IDE) antibody produced in rabbit, ,
Reatividade de espécies
human, mouse, rat
Aplicação
western blot
Anti-IDE Antibody, clone 1J8 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reatividade de espécies
human, mouse, rat
Aplicação
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot
Anti-IDE, N-Terminal (97-273) Rabbit pAb, liquid, Calbiochem®,
Reatividade de espécies
hamster, human, mouse, rat
Aplicação
Anti-IDE antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reatividade de espécies
human
Aplicação
immunohistochemistry
western blot
Anti-IDE antibody produced in rabbit, ,
Reatividade de espécies
human, mouse
Aplicação
immunofluorescence
western blot

esiRNA

Número do produto
Descrição
Espécies
MISSION® esiRNA, targeting human IDE,
Espécies
human
MISSION® esiRNA, targeting mouse Ide,
Espécies
mouse