ERBB2
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
Sinônimos:
CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1
Espécies:
Human ERBB2 (2064), Mouse Erbb2 (13866), Rat Erbb2 (24337), domestic guinea pig Erbb2 (100727657), naked mole-rat Erbb2 (101705227), Zebrafish erbb2 (386966), chicken ERBB2 (426130), dog ERBB2 (403883), domestic cat ERBB2 (751824), Horse ERBB2 (100054739) ...Mais
ID UniProtKB:
ID do gene:
- Human(2064) Summary: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
- Mouse(13866) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- Rat(24337) v-erb-b2 avian erythroblastic leukemia viral oncogene 2
- domestic guinea pig(100727657) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- naked mole-rat(101705227) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- Zebrafish(386966) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
- chicken(426130) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
- dog(403883) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- domestic cat(751824) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- Horse(100054739) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- cow(505709) v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
- sheep(780519) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- Domestic Rabbit(100009554) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
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ELISA
Antibodies
Número do produto
Descrição
Reatividade de espécies
Aplicação
Anti-c-ErbB2/c-Neu (Ab-3) Mouse mAb (3B5), liquid, clone 3B5, Calbiochem®,
Reatividade de espécies
human, mouse
Aplicação
Anti-HER2 antibody, Rabbit monoclonal, recombinant, expressed in HEK 293 cells, clone RM228, purified immunoglobulin,
Reatividade de espécies
human
Aplicação
immunohistochemistry
western blot
western blot
Anti-c-ErbB2/c-Neu (Ab-4) Mouse mAb (7.16.4), liquid, clone 7.16.4, Calbiochem®,
Reatividade de espécies
human, rat
Aplicação
Alpaca Anti-Her2, recombinant single domain Antibody, Recombinant Alpaca (VHH) Nano antibody,
Reatividade de espécies
human
Aplicação
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-ERBB2 antibody produced in rabbit, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reatividade de espécies
human
Aplicação
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Cell Lines
Small Molecule - Inhibitor
Proteins
Número do produto
Descrição
Espécies
ErbB2/HER2/CD340 human, recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE),
Espécies
human