ABCC5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
Sinônimos:
ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11
Espécies:
Human ABCC5 (10057), Mouse Abcc5 (27416), Rat Abcc5 (116721), Zebrafish abcc5 (336147), domestic guinea pig Abcc5 (100723026), naked mole-rat Abcc5 (101718472), Domestic Rabbit ABCC5 (100351084), sheep ABCC5 (101123431), cow ABCC5 (511769), domestic cat ABCC5 (101090542) ...Mais
ID UniProtKB:
ID do gene:
- Human(10057) Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. [provided by RefSeq, Jul 2008]
- Mouse(27416) ATP-binding cassette, sub-family C (CFTR/MRP), member 5
- Rat(116721) ATP-binding cassette, subfamily C (CFTR/MRP), member 5
- Zebrafish(336147) ATP-binding cassette, sub-family C (CFTR/MRP), member 5
- domestic guinea pig(100723026) ATP-binding cassette, sub-family C (CFTR/MRP), member 5
- naked mole-rat(101718472) ATP-binding cassette, sub-family C (CFTR/MRP), member 5
- Domestic Rabbit(100351084) ATP-binding cassette, sub-family C (CFTR/MRP), member 5
- sheep(101123431) ATP-binding cassette, sub-family C (CFTR/MRP), member 5
- cow(511769) ATP-binding cassette, sub-family C (CFTR/MRP), member 5
- domestic cat(101090542) ATP-binding cassette, sub-family C (CFTR/MRP), member 5
- Horse(100066941) ATP-binding cassette, sub-family C (CFTR/MRP), member 5
- dog(478648) ATP-binding cassette, sub-family C (CFTR/MRP), member 5
- chicken(424947) ATP-binding cassette, sub-family C (CFTR/MRP), member 5
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Antibodies
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Aplicação
Anti-ABCC5 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reatividade de espécies
human
Aplicação
immunohistochemistry
Anti-ABCC5 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reatividade de espécies
human
Aplicação
immunofluorescence
Monoclonal Anti-ABCC5 antibody produced in mouse, clone 1B12, purified immunoglobulin, buffered aqueous solution,
Reatividade de espécies
human
Aplicação
ELISA
western blot
western blot
Cell Lines
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Proteins
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esiRNA
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