Baran Group – Professor Product Portal
Professor Phil S. Baran
The Baran Group provides a portfolio of zinc-based reagents promoting difluoromethylation, trifluoromethylation, trifluoroethylation and isopropylation of aryl and heteroaryl motifs. Baran’s lab has also helped introduce a portable desaturase (Tz0Cl), which promotes the installation of alcohol and amine groups and leaves behind a highly useful tosyl group for further transformations.
Phil Baran has developed a zinc sulfinate toolkit containing products available in our catalog (TFMS, DFMS, TFES, and IPS) for the simple and rapid diversification of heterocycles found in the Nature paper "Practical and Innate Carbon-Hydrogen Functionalization of Heterocycles."
Recent articles from the Baran Laboratory:
1.
Zhou Q, Gui J, Pan C, Albone E, Cheng X, Suh EM, Grasso L, Ishihara Y, Baran PS. 2013. Bioconjugation by Native Chemical Tagging of C?H Bonds. J. Am. Chem. Soc.. 135(35):12994-12997. https://doi.org/10.1021/ja407739y
2.
O?Hara F, Blackmond DG, Baran PS. 2013. Radical-Based Regioselective C?H Functionalization of Electron-Deficient Heteroarenes: Scope, Tunability, and Predictability. J. Am. Chem. Soc.. 135(32):12122-12134. https://doi.org/10.1021/ja406223k
Products available from the Baran Laboratory
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DISCIPLINES
- Organic Synthetic Chemistry
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