SCP0170
Granulocyte Elastase Substrate human
≥95% (HPLC), lyophilized
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10 MG
R$926.00
R$926.00
Estimated to ship onApril 18, 2025
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10 MG
R$926.00
About This Item
Empirical Formula (Hill Notation):
C21H27N5O6
Molecular Weight:
445.47
UNSPSC Code:
12352204
NACRES:
NA.32
R$926.00
Estimated to ship onApril 18, 2025
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Product Name
Granulocyte Elastase Substrate human,
Assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥85%
storage condition
protect from light
storage temp.
−20°C
Related Categories
Amino Acid Sequence
Glp-Pro-Val-pNA
General description
Biochem/physiol Actions
Elastase is a catalytic enzyme that catalyzes the cleavage of carboxyl groups on tiny hydrophobic amino acids including glycine, alanine, and valine. Its main function is to break down elastin.[4] Free elastase in some purulent synovial fluids plays a key role in articular cartilage breakdown. Increased elastase levels in the plasma have been seen in patients with evident rheumatoid arthritis.[3]
Elastase(s) can be assayed and differentiated using chromogenic and fluorogenic Pro-Val peptide substrates such as Glp-Pro-Val-pNA and MeOSuc-Ala-Ala-Pro-Val-4-MNA.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Evaluation of exocrine pancreatic function
Cotton SW
Contemporary Practice in Clinical Chemistry, 573-585 (2020)
Use of Extracts from Squirting Cucumber (Ecballium elaterium) Seeds in Health
Attard E
Nuts and Seeds in Health and Disease Prevention, 1079-1086 (2011)
K Kleesiek et al.
Rheumatology international, 6(4), 161-169 (1986-01-01)
Human granulocyte elastase (EC 3.4.21.37) is released from granulocytes in large amounts in chronic inflammatory joint diseases and is therefore of special pathogenic and diagnostic importance. In order to examine the diagnostic significance of this enzyme as a clinico-chemical parameter
Effects of Nigella (Nigella sativa L.) Seed Extract on Human Neutrophil Elastase Activity
Kacem R
Nuts and Seeds in Health and Disease Prevention, 823-829 (2011)
Pier Carlo Braga et al.
Pharmacology, 77(3), 150-154 (2006-07-11)
Erdosteine is a mucolytic drug whose metabolization gives rise to an active metabolite with an SH group (Met I), which reduces neutrophil release of reactive oxygen species and the peroxynitrite generated by the reaction of superoxide anion with nitric oxide
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