810226P
Avanti
C6-NBD Lactosyl Ceramide
Avanti Research™ - A Croda Brand 810226P, powder
Synonym(s):
N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-lactosyl-β1-1′-sphingosine
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C42H69N5O16
CAS Number:
Molecular Weight:
900.02
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
Pricing and availability is not currently available.
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (810226P-1MG)
pkg of 1 × 250 μg (810226P-250ug)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810226P
shipped in
dry ice
storage temp.
−20°C
General description
Application
C6-NBD Lactosyl Ceramide has been used in:
- lactosylceramide synthase assay as a fluorescent acceptor substrate identified using fluorescence based detector in HPLC(1)
- phospholipid labeling and fluorescence-lifetime imaging microscopy (FILM) of cell membranes(6)
Biochem/physiol Actions
Lactosyl ceramide is utilized for synthesis of various glycosphingolipids like oligoglycosylceramides and gangliosides in vertebrates. It is an important molecule involved in signaling cascades leading to phenotypic changes such as adhesion, migration, cell proliferation and angiogenesis.[2][3][4][5]
Packaging
5 mL Amber Glass Screw Cap Vial (810226P-1MG)
5 mL Amber Glass Screw Cap Vial (810226P-250ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.
If you need assistance, please contact Customer Support.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Yasuhiro Hayashi et al.
Analytical biochemistry, 345(2), 181-186 (2005-09-06)
Glucosylceramide synthase (GlcT) and lactosylceramide synthase (GalT) are key enzymes for the synthesis of major glycosphingolipids of vertebrates. In this article, we report a new reliable method to determine GlcT and GalT activities using the fluorescent acceptor substrates C6-4-nitrobenzo-2-oxa-1,3-diazole (NBD)-ceramide
S Hakomori et al.
Journal of biochemistry, 118(6), 1091-1103 (1995-12-01)
Glycosphingolipids (GSLs), cell type-specific markers which change dramatically during ontogenesis and oncogenesis, have been implicated as playing major roles in cellular interactions and control of cell proliferation in multicellular organisms. These functional roles have been partially clarified through two types
Subroto Chatterjee et al.
Biochimica et biophysica acta, 1780(3), 370-382 (2007-12-14)
Although lactosylceramide (LacCer) plays a pivotal role in the biosynthesis of nearly all the major glycosphingolipids, its function in regulating cellular function has begun to emerge only recently. Our current opinion is that several physiologically critical molecules such as modified/oxidized
W I Weis et al.
Annual review of biochemistry, 65, 441-473 (1996-01-01)
Lectins are responsible for cell surface sugar recognition in bacteria, animals, and plants. Examples include bacterial toxins; animal receptors that mediate cell-cell interactions, uptake of glycoconjugates, and pathogen neutralization; and plant toxins and mitogens. The structural basis for selective sugar
Ana Zarubica et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 23(6), 1775-1785 (2009-01-20)
The ABCA1 transporter orchestrates cellular lipid homeostasis by promoting the release of cholesterol to plasmatic acceptors. The molecular mechanism is, however, unknown. We report here on the biophysical analysis in living HeLa cells of the ABCA1 lipid microenvironment at the
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
