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Deoxycorticosterone acetate

98%

Synonym(s):

11-Deoxycorticosterone acetate, 21-Acetoxy-4-pregnene-3,20-dione, 21-Acetoxyprogesterone, 21-Hydroxy-4-pregnene-3,20-dione 21-acetate, 21-Hydroxyprogesterone 21-acetate, 4-Pregnen-21-ol-3,20-dione 21-acetate, Cortexone acetate, DOC acetate

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About This Item

Empirical Formula (Hill Notation):
C23H32O4
CAS Number:
56-47-3
Molecular Weight:
372.50
Beilstein:
2570798
EC Number:
200-275-9
MDL number:
MFCD00003660
UNSPSC Code:
12352200
PubChem Substance ID:
329753238

Assay

98%

form

solid

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@]([H])(CC[C@@]24[H])C(=O)COC(C)=O

InChI

1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1

InChI key

VPGRYOFKCNULNK-ACXQXYJUSA-N

Gene Information

human ... NR3C2(4306)

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Certificates of Analysis (COA)

Lot/Batch Number
12009BF
01004CV
16325HR
10904BF
08425BF

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Jiang Xu et al.
American journal of physiology. Heart and circulatory physiology, 299(5), H1328-H1338 (2010-09-14)
Angiotensin II (ANG II) contributes to hypertension, cardiac hypertrophy, fibrosis, and dysfunction; however, it is difficult to separate the cardiac effect of ANG II from its hemodynamic action in vivo. To overcome the limitations, we used transgenic mice with cardiac-specific
D H Vandorpe et al.
Canadian journal of physiology and pharmacology, 69(11), 1784-1788 (1991-11-01)
Rebound metabolic alkalosis is a transient alkalemia that is seen during recovery from NH4Cl-induced metabolic acidosis. The persistent elevation of plasma bicarbonate concentration is the result of continuing excretion of net acid by the kidney. Bicarbonate transport by inner medullary
Volker Vallon et al.
Journal of molecular medicine (Berlin, Germany), 84(5), 396-404 (2006-04-11)
The mineralocorticoids aldosterone and deoxycorticosterone acetate (DOCA) stimulate renal tubular salt reabsorption, increase salt appetite, induce extracellular volume expansion, and elevate blood pressure. Cardiac effects of mineralocorticoids include stimulation of matrix protein deposition leading to cardiac fibrosis, which is at
Susana Cavallero et al.
American journal of physiology. Heart and circulatory physiology, 298(4), H1290-H1299 (2010-02-09)
Hemodynamic parameters and natriuretic peptide levels were evaluated in cardiac hypertrophy produced by sequentially applied renovascular (RV) and deoxycorticosterone acetate-salt (DS) models of hypertension. We studied hypertensive rats by RV or DS treatment at 2 and 4 wk, as well
Cheng-Chao Ruan et al.
Arteriosclerosis, thrombosis, and vascular biology, 30(12), 2568-2574 (2010-09-25)
To examine the role of perivascular adipose tissue (PVAT)-derived factors in the regulation of adventitial fibroblast (AF) function in vitro and in vivo. PVAT is an active component of blood vessels. Bioactive substances released from PVAT play regulatory roles in
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