12021AST
Astec® CHIROBIOTIC® T Chiral (5 μm) HPLC Columns
L × I.D. 5 cm × 4.6 mm, HPLC Column
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About This Item
UNSPSC Code:
41115700
eCl@ss:
32110501
NACRES:
SB.52
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product name
Astec® CHIROBIOTIC® T Chiral HPLC Column, 5 μm particle size, L × I.D. 5 cm × 4.6 mm
material
stainless steel column
Quality Level
Agency
suitable for USP L63
description
HPLC column
product line
Astec®
packaging
pkg of 1 ea
manufacturer/tradename
Astec®
parameter
0-45 °C temperature
241 bar pressure (3500 psi)
technique(s)
HPLC: suitable
LC/MS: suitable
L × I.D.
5 cm × 4.6 mm
matrix
High-purity silica gel particle platform
fully porous particle
matrix active group
teicoplanin glycopeptide phase
particle size
5 μm
pore size
100 Å
operating pH range
3.8-6.8
separation technique
chiral
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General description
CHIROBIOTIC® T and T2 have teicoplanin as the chiral selector. They offer unique selectivity for a number of classes of molecules, specifically underivatized α, β, γ and cyclic amino acids, N-derivatized amino acids, hydroxy-carboxylic acids, acidic compounds including carboxylic acids and phenols, small peptides, neutral aromatic analytes and cyclic aromatic and aliphatic amines. Separations normally obtained on a chiral crown ether or ligand exchange-type CSPs are also possible on the CHIROBIOTIC® T and T2, but in much simpler mobile phases, like water-alcohol. In addition, all of the known beta-blockers (amino alcohols), and dihydrocoumarins have been resolved. CHIROBIOTIC® T and T2 differ in their bonding chemistry and the pore size of the support particle, giving them different selectivity and preparative capacity.
CHIROBIOTIC FAQs
CHIROBIOTIC Reference Bibliography
Chiral Product Literature
- Bonded phase: Teicoplanin
- Operating pH range: 3.8 - 6.8
- Particle diameter: 5, 10 or 16 μm
- Pore size: 100 Å (CHIROBIOTIC® T) or 200 Å (CHIROBIOTIC® T2)
CHIROBIOTIC FAQs
CHIROBIOTIC Reference Bibliography
Chiral Product Literature
Legal Information
Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC
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Berit P Jensen et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 865(1-2), 48-54 (2008-03-07)
A stereoselective liquid chromatography-tandem mass spectrometry assay was developed and validated for quantification of S- and R-metoprolol at concentrations of 0.5-50 microg/L in human plasma. Metoprolol was extracted from plasma by liquid-liquid extraction with ethyl acetate (82% recovery). Chromatographic separation
D Abd el-Hady et al.
Journal of pharmaceutical and biomedical analysis, 37(5), 919-925 (2005-05-03)
A simple, sensitive and selective high performance liquid chromatographic method with UV detection for the chiral separation of racemic methotrexate (rac-Mtx) and enantiomeric purity of L-methotrexate in pharmaceutical formulations was developed and validated. The chiral separation was optimized studying both
Syntheses of racemic and non-racemic silicon- and germanium-containing a-amino acids of the formula type H2NCH(CH2ElR3)COOH (El=Si, Ge; R=organyl) and incorporation of d-H2NCH(CH2SiMe3)COOH and d-H2NCH(CH2GeMe3)COOH into biologically active decapeptides: a study on C/Si/Ge bioisosterism
Merget, Markus, et al.
Journal of Organometallic Chemistry, 628 (2), 183-194 (2001)
P Jander et al.
Journal of chromatography. A, 919(1), 67-77 (2001-07-19)
The retention behaviour of the enantiomers of underivatized phenylglycine was studied on a Chirobiotic T column packed with amphoteric glycopeptide teicoplanin covalently bonded to the surface of silica gel. The retention and the selectivity of separation of the enantiomers increase
Yuan-Qing Xia et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 788(2), 317-329 (2003-04-23)
An automated online sample extraction method for rat plasma was developed and validated for the quantification of (R)- and (S)-propranolol following the intravenous administration of either the racemate or the individual enantiomers at 5 mg/kg. A dual-column extraction system coupled
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