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V900421

Sigma-Aldrich

Uridine

Vetec™, reagent grade, 99%

Synonyme(s) :

1-β-D-Ribofuranosyluracil, Uracil-1-β-D-ribofuranoside

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About This Item

Formule empirique (notation de Hill) :
C9H12N2O6
Numéro CAS:
58-96-8
Poids moléculaire :
244.20
Beilstein:
754902
Numéro MDL:
MFCD00006526
Code UNSPSC :
12352204
ID de substance PubChem :
329829829
Le tarif et la disponibilité ne sont pas disponibles actuellement.

Qualité

reagent grade

Gamme de produits

Vetec™

Essai

99%

Forme

powder

Pf

163-167 °C (lit.)

Chaîne SMILES 

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=O)NC2=O

InChI

1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1

Clé InChI

DRTQHJPVMGBUCF-XVFCMESISA-N

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Description générale

Uridine is a pyrimidine nucleoside composed of uracil and ribose that is readily taken up by the brain.[1] This compound is synthesized de novo in mammals. It is found circulating in the blood and cerebrospinal fluid.[2]

Actions biochimiques/physiologiques

Uridine is an essential compound involved in maintaining cellular function and energy metabolism. It aids in multiple biological processes, including RNA synthesis, the synthesis of biomembranes, and glycosylation.[3] Furthermore, uridine serves as a precursor molecule for UDP-glucose, a vital component in the synthesis and storage of glycogen in the liver.[4] In addition, studies have shown that uridine reduces cytotoxicity and improves neurophysiological functions.[2] It is involved in regulating various normal physiological processes in the body, including the cardio-circulatory, reproductive, peripheral and central nervous, and respiratory systems.[5]

Informations légales

Vetec is a trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
WXBF5274V
WXBF3286V
WXBF1674V
WXBD6953V
WXBD8453V

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Juma A M Ali et al.
Molecular pharmacology, 83(2), 439-453 (2012-11-29)
African trypanosomes are capable of both pyrimidine biosynthesis and salvage of preformed pyrimidines from the host. However, uptake of pyrimidines in bloodstream form trypanosomes has not been investigated, making it difficult to judge the relative importance of salvage and synthesis
Che C Colpitts et al.
Journal of virology, 87(7), 3640-3654 (2013-01-04)
Entry of enveloped viruses requires fusion of viral and cellular membranes. Fusion requires the formation of an intermediate stalk structure, in which only the outer leaflets are fused. The stalk structure, in turn, requires the lipid bilayer of the envelope
Yuan Zhou et al.
Nucleic acids research, 41(13), 6664-6673 (2013-05-10)
Triplex is emerging as an important RNA tertiary structure motif, in which consecutive non-canonical base pairs form between a duplex and a third strand. RNA duplex region is also often functionally important site for protein binding. Thus, triplex-forming oligonucleotides (TFOs)
G P Connolly et al.
Trends in pharmacological sciences, 20(5), 218-225 (1999-06-04)
There are many disorders of pyrimidine metabolism and those that involve an alteration in uridine metabolism have neurological and systemic effects, which provide insights into the biological activity of uridine and its analogues. Studies of the metabolism and actions of
Ian E Crandall et al.
Journal of medicinal chemistry, 56(6), 2348-2358 (2013-02-16)
Resistance by Plasmodium falciparum to almost all clinically used antimalarial drugs requires the development of new classes of antimalarials. 6-Iodouridine (15), a novel and potent inhibitor of orotidine 5'-monophosphate decarboxylase (ODCase), exhibited efficacy in a mouse model infected by P.
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