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Principaux documents

SRP6024

Sigma-Aldrich

Ubiquitin Aldehyde human

recombinant, expressed in E. coli, ≥95% (HPLC)

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About This Item

Code UNSPSC :
12352200
Nomenclature NACRES :
NA.32

Source biologique

human

Produit recombinant

expressed in E. coli

Essai

≥95% (HPLC)

Forme

liquid

Poids mol.

8.5 kDa

Conditionnement

pkg of 50 μg

Technique(s)

protein purification: suitable

Impuretés

Endotoxin, tested

Numéro d'accès NCBI

P62988

Numéro d'accès UniProt

P62987

Conditions d'expédition

dry ice

Température de stockage

−70°C

Informations sur le gène

human ... UBA2(7311)

Description générale

Ubiquitin Aldehyde was first synthesized by the reduction by borohydride of ubiquitin thioester, produced by the dehydration of the binary-ubiquitin-UCH-L3 (ubiquitin C-terminal hydrolase L3) complex.[1]

Application

Ubiquitin Aldehyde human has been added to protein homogenates during the purification of ubiquitinated proteins.[2]

Actions biochimiques/physiologiques

Ubiquitin Aldehyde is a synthetic inhibitor of isopeptidases, proteins that hydrolyze the bond between Ub (ubiquitin) polypeptide and its protein adduct. In β-thalassemia, anemia results due to insufficiency in hemoglobin (Hb) β-subunit synthesis which leads to excess amounts of Hbα subunits, resulting in erythroid cell hemolysis. Studies show that ubiquitin aldehyde increases the proteolysis of Hbα subunits, therefore, preventing hemolysis. Hence, this might have potential as a therapeutic approach to treatment of β-thalassemia.[3]

Forme physique

An aqueous solution containing 0.15 M HCl

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
9F244845
70945
70245

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Ubiquitin and the Biology of the Cell
Peters JM et al
Springer Science & Business Media (2013)
J R Shaeffer et al.
Blood, 90(3), 1300-1308 (1997-08-01)
Two major causes of the anemia in beta-thalassemia are a deficiency in hemoglobin (Hb) beta-subunit (and consequently HbA) synthesis and, due to the resulting excess of Hb alpha-subunits, erythroid cell hemolysis. The hemolytic component might be ameliorated by increasing the
Hu-Hui Chen et al.
Molecular plant, 11(5), 706-719 (2018-03-06)
Unveiling the signal transduction of phytohormone abscisic acid (ABA) and its regulatory mechanisms is critical for developing the strategies toward improving plant responses to stressful environments. ABA signaling is perceived and mediated by multiple PYR/PYL receptors, whose post-translational modifications, especially
Lingyao Kong et al.
Nature communications, 6, 8630-8630 (2015-10-21)
Clade A protein phosphatase 2Cs (PP2Cs) are abscisic acid (ABA) co-receptors that block ABA signalling by inhibiting the downstream protein kinases. ABA signalling is activated after PP2Cs are inhibited by ABA-bound PYR/PYL/RCAR ABA receptors (PYLs) in Arabidopsis. However, whether these

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