SRP5304

PDGFR-α (T674I), active, GST tagged human

PRECISIO^®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Synonyme(s) : CD140A, MGC74795, PDGFR2, Rhe-PDGFRA
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.32

Propriétés

• Produit recombinant: expressed in baculovirus infected Sf9 cells
• Gamme de produits: PRECISIO^®
• Pureté: ≥70% (SDS-PAGE)
• Forme: buffered aqueous glycerol solution
• Activité spécifique: 16-24 nmol/min·mg
• Poids mol.: ~95 kDa
• Numéro d'accès NCBI: NM_006206
• Conditions d'expédition: dry ice
• Température de stockage: −70°C
• Informations sur le gène: human ... PDGFRA(5156)

Description

Description générale

PDGFR alpha (platelet-derived growth factor receptor a) is a member of the PDGFR family of membrane receptors with intrinsic tyrosine kinase activity. Aberrant expression of PDGFR alpha has been linked to developmental abnormalities in vertebrate models and has been implicated in multiple disease states in humans. There is widespread expression of PDGFR alpha in renal cell types involved in fibrotic and sclerosing processes. PDGF and its receptor PDGFR alpha are inducers of fibrosis in the repair phase of inflammatory bowel disease and they may also be involved in the active inflammatory phase. PDGFRa(T674I) is one of the mutant forms of PDGFRa.

Forme physique

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

Notes préparatoires

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

Informations légales

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable