SML1851

RI(dl)-2

≥98% (HPLC)

• Synonyme(s) : N-Ethyl-4-(pyrrolo[1,2-a]quinoxalin-4-yl)aniline
• Formule empirique (notation de Hill): C₁₉H₁₇N₃ · xC₂HF₃O₂
• Numéro CAS: 1902146-75-1
• Poids moléculaire : 287.36 (free base basis)
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: , light orange to dark red
• Solubilité: DMSO: 20 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: CCNC1=CC=C(C2=NC3=C(N4C2=CC=C4)C=CC=C3)C=C1.FC(F)(C(O)=O)F
• InChI: 1S/C19H17N3.C2HF3O2/c1-2-20-15-11-9-14(10-12-15)19-18-8-5-13-22(18)17-7-4-3-6-16(17)21-19;3-2(4,5)1(6)7/h3-13,20H,2H2,1H3;(H,6,7)
• Clé InChI: NIJZNZBFNNPMPH-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

RI(dl)-2 is a cell-permeable pyrroloquinoxaline derivative that selectively inhibits Rad51-mediated D-loop formation (IC₅₀ = 11.1 μM) without affecting its ssDNA-binding activity (IC₅₀ >100 μM). RI(dl)-2 is shown to inhibit DSBs-induced cellular homologous recombination (HR) activity (IC₅₀ = 3.0 μM by HEK293-based DR-GFP reporter assay) by stabilizing nucleoprotein filaments in a nonfunctional state without affecting DNA damage-induced RAD51 nuclear loci formation or stimulating single-strand annealing (SSA) activity.

RI(dl)-2 is a cell-permeable pyrroloquinoxaline derivative that selectively inhibits Rad51-mediated D-loop formation.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable