Accéder au contenu
Merck
Toutes les photos(1)

Documents

SMB00286

Sigma-Aldrich

Terconazole

≥98%

Synonyme(s) :

(+-)-1-{4-[cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxy]phenyl}-4-isopropylpiperazine, Triaconazole

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Formule empirique (notation de Hill):
C26H31Cl2N5O3
Numéro CAS:
67915-31-5
Poids moléculaire :
532.46
Numéro CE :
267-751-6
Code UNSPSC :
51101500
Nomenclature NACRES :
NA.85

Pureté

≥98%

Forme

powder

Couleur

white

Solubilité

DMSO: 1 mg/mL

Spectre d'activité de l'antibiotique

fungi

Mode d’action

enzyme | interferes

Température de stockage

2-8°C

InChI

1S/C26H31Cl2N5O3/c1-19(2)31-9-11-32(12-10-31)21-4-6-22(7-5-21)34-14-23-15-35-26(36-23,16-33-18-29-17-30-33)24-8-3-20(27)13-25(24)28/h3-8,13,17-19,23H,9-12,14-16H2,1-2H3/t23-,26-/m0/s1

Clé InChI

BLSQLHNBWJLIBQ-OZXSUGGESA-N

Vous recherchez des produits similaires ? Visite Guide de comparaison des produits

Description générale

Terconazole is a traizole ketal derivative, which is antifungal in nature. It is especially effective against Candidal spp.

Application

Terconazole could be used for the assessment of the effect of terconazole on transduction efficiency of host cells by glycoprotein of Ebola virus (EBOV), and for the assessment of the effect of terconazole on transduction efficiency of embryonic kidney cell line 293T by human coronaviruses.

Actions biochimiques/physiologiques

Terconazole suppresses the growth of various types of yeats and mycelium-forming fungi in in vitro conditions. Its antifungal activity is an outcome of the accumulation of the membrane-disrupting 14α-demethylsterols and ergosterol depletion. This is result of inactivation of cytochrome P-450-dependent 14α-demethylase by terconazole. It is a rapidly-acting and well-tolerated antifungal used for the treatment of vulvovaginal candidiasis. It is also used for the treatment of dermatophytosis and candidosis. The drug may facilitate the accumulation of cholesterol in late endosomes.

Conditionnement

2MG

Stockage et stabilité

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids

Autres remarques

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place. Storage class (TRGS 510): Non Combustible Solids

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335,H413

Classification des risques

Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Les clients ont également consulté

Slide 1 of 1

1 of 1

Tamoxifène ≥99%

Sigma-Aldrich

T5648

Tamoxifène

J Van Cutsem et al.
Chemotherapy, 29(5), 322-331 (1983-01-01)
Terconazole, a new triazole ketal, is found to be highly active in vitro on a wide range of yeasts and mycelium-forming fungi. The in vitro activity depends largely on the medium used. In vitro it is a potent antifungal agent
Heike Hofmann-Winkler et al.
The Journal of infectious diseases, 212 Suppl 2, S172-S180 (2015-04-04)
The ongoing Ebola virus (EBOV) disease (EVD) epidemic in Western Africa is the largest EVD outbreak recorded to date and requires the rapid development and deployment of antiviral measures. The viral glycoprotein (GP) facilitates host cell entry and, jointly with
E L Tolman et al.
Antimicrobial agents and chemotherapy, 29(6), 986-991 (1986-06-01)
Terconazole is a new triazole ketal derivative with broad-spectrum in vitro and in vivo antifungal activities. This study further characterizes the effects of terconazole in vitro on yeast cell growth, viability, and morphology. Terconazole inhibited the growth of Candida albicans
Florian Wrensch et al.
Viruses, 6(9), 3683-3698 (2014-09-27)
The interferon-inducible transmembrane (IFITM) proteins 1, 2 and 3 inhibit the host cell entry of several enveloped viruses, potentially by promoting the accumulation of cholesterol in endosomal compartments. IFITM3 is essential for control of influenza virus infection in mice and
Ting Li et al.
Medical mycology, 53(5), 455-461 (2015-04-17)
Terconazole is a new, broad-spectrum, triazole antifungal agent. The aim of this study was to compare the efficacy and safety of a 6-day course of a terconazole vaginal suppository (80 mg) with two doses of oral fluconazole (150 mg) for
Afficher tous les articles scientifiques apparentés

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique