Accéder au contenu
Merck
Toutes les photos(1)

Principaux documents

SCP0169

Sigma-Aldrich

HIV-1 Tat Peptide

HIV-TAT (48-57)
1 of 1 reviewers received a sample product or took part in a promotion

≥95% (HPLC), lyophilized powder

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme

Sélectionner une taille de conditionnement

1 MG
187,00 €

187,00 €


Veuillez contacter notre Service Clients pour connaître la disponibilité de ce produit.


Sélectionner une taille de conditionnement

Changer de vue
1 MG
187,00 €

About This Item

Formule empirique (notation de Hill):
C65H124N34O13
Poids moléculaire :
1589.90
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

187,00 €


Veuillez contacter notre Service Clients pour connaître la disponibilité de ce produit.

Nom du produit

HIV-TAT (48-57),

Essai

≥95% (HPLC)

Forme

lyophilized

Composition

Peptide Content, ≥55%

Conditions de stockage

protect from light

Température de stockage

−20°C

Amino Acid Sequence

Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-NH2

Description générale

Human immunodeficiency virus (HIV)-transactivator of transcription (Tat), a regulatory protein is coded by the Tat gene of HIV-1. Tat is made up of two exons, highly conserved regions, and subtype-specific regions.[1]

Actions biochimiques/physiologiques

Human immunodeficiency virus (HIV)-transactivator of transcription (Tat) participates in the pathogenesis of HIV-related complications. Tat protein is also involved in HIV-related cardiac dysfunction.[1] HIV-TAT (48-57) is used to facilitate the internalization of synthetic peptides.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number

Vous ne trouvez pas la bonne version ?

Si vous avez besoin d'une version particulière, vous pouvez rechercher un certificat spécifique par le numéro de lot.

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Yanan Jiang et al.
Journal of translational medicine, 16(1), 121-121 (2018-05-10)
The human immunodeficiency virus (HIV) is a major global public health issue. HIV-related cardiovascular disease remains a leading cause of morbidity and mortality in HIV positive patients. HIV Tat is a regulatory protein encoded by tat gene of HIV-1, which
S-M Lee et al.
Clinical and experimental immunology, 161(3), 504-511 (2010-07-22)
The immune receptor expressed on myeloid cells 1 (IREM-1) has been known to regulate the activities of myeloid cells through its immunoreceptor tyrosine-based inhibition motifs (ITIMs) in its intracellular region. In order to investigate its effect on macrophage activation, a
S-M Lee et al.
Clinical and experimental immunology, 167(3), 438-446 (2012-02-01)
The immune receptor expressed on myeloid cells 1 (IREM-1/CD300F) has been shown to inhibit various inflammatory processes in myeloid cells, such as macrophages and mast cells. IREM-1 exerts its inhibitory effect through its intracellular immunoreceptor tyrosine-based inhibition motifs (ITIMs). In

Questions

Reviews

1 of 1 reviewers received a sample product or took part in a promotion

Active Filters

    • Review 1
    • Votes 2
    1 out of 5 stars.

    Purchase a different product

    Quite disappointed in this product. For one, they do not provide any information on reconstitution of this lyophilized powder, not even whether to use dH20 or not. Additionally, please look closely at the 3 cited papers that allegedly used this product. One is a review that didn't actually use the product, and the other two are from the same lab that published what looks to be the same experiment twice, but without sufficient methodology. They list that, "Fusion proteins containing ITIMs and HIV-TAT48–57 and its negative control containing only HIV-TAT48–57 were custom-designed and synthesized by Peptron Inc. (Daejeon, Korea)" which is not this product? Additionally, their only methodology in terms of use does not include reconstitution, merely this sentence hidden below a figure, "Cells were pre-treated with 5 µM of TAT, TAT–YADL, TAT–YVTM, TAT–YASL, TAT–YCNM or TAT–YSTI for 30 min before stimulation with 1 µg/ml of lipopolysaccharide (LPS) for 24 h."

    When I contacted a rep about my concerns they said they couldn't help with reconstitution instructions and I should have checked to see if they had instructions before purchasing.... a less than stellar response. Save yourself the time, money, and hassle and find a different product.

    Helpful?

    1. Response from MilliporeSigma:

      Thank you for taking the time to leave a review. We are sorry to hear that your experience did not meet expectations. Our Technical Service team has reached out to you with additional resources in effort to resolve this issue. We apologize for any inconvenience this may have caused.

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique