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SAB4501939

Sigma-Aldrich

Anti-B-MYB antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

BMYB, MYBB, MYBL2, Myb-related protein B

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 79 kDa

Espèces réactives

mouse, human, rat

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:20000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

Numéro d'accès NCBI

P10244

Numéro d'accès UniProt

P10244

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... MYBL2(4605)

Description générale

MYB proto-oncogene like 2/v-myb avian myeloblastosis viral oncogene homolog-like 2 (MYBL2/B-MYB) belongs to the MYB family of transcription factors. MYBL2 gene is located on human chromosome 20q13.

Immunogène

The antiserum was produced against synthesized peptide derived from human B-Myb.

Immunogen Range: 551-600

Actions biochimiques/physiologiques

MYB proto-oncogene like 2/v-myb avian myeloblastosis viral oncogene homolog-like 2 (MYBL2/B-MYB) protein regulates cell proliferation, differentiation, and DNA repair. It participates in DNA replication in embryonic stem cells. MYBL2 protein can modulate stem cell genes. MYBL2 gene expression is altered in breast, ovarian, liver, colon, rectal, blood, brain, and bladder cancers. MYBL2 affects cell cycle progression and apoptosis in a regulated manner. It serves as a cell cycle modulator in hepatocellular carcinoma (HCC).

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Z Guan et al.
Current research in translational medicine, 66(1), 27-32 (2017-12-25)
In this study, we aimed to assess the association between MYBL2 expression/transcription regulatory activity (TRA) and overall survival (OS) in patients with primary hepatocellular carcinoma (HCC) and to explore the factors related to B-Myb TRA. Bioinformatic analysis was performed based
Rachel Bayley et al.
Biochimica et biophysica acta. Reviews on cancer, 1874(2), 188407-188407 (2020-08-28)
The MYBL2 gene, also known as B-MYB, is essential to regulate vital cellular processes including cell proliferation, differentiation and DNA repair. Changes in these pathways can facilitate cancer development and as such targeting these processes represent an effective method to

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