SAB4300090

Anti-phospho-MAPT (pSer²⁶²) antibody produced in rabbit

affinity isolated antibody

• Synonyme(s) : Anti-DDPAC antibody produced in rabbit, Anti-FLJ31424 antibody produced in rabbit, Anti-FTDP-17 antibody produced in rabbit, Anti-MAPTL antibody produced in rabbit, Anti-microtubule-associated protein tau antibody produced in rabbit
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: ~48 kDa; ~62 kDa; ~78 kDa
• Espèces réactives: rat, human, mouse
• Concentration: 1 mg/mL
• Technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• Isotype: IgG
• Séquence immunogène: (I-G-SP-T-E)
• Numéro d'accès NCBI: NP_001116538.1
• Numéro d'accès UniProt: P10636
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: phosphorylation (pSer262)
• Informations sur le gène: human ... MAPT(4137)

Description

Description générale

MAPT (microtubule associated protein tau) is located on human chromosome 17q21.3 It is highly expressed in neurons but is most prominent in axons

Immunogène

Peptide sequence around phosphorylation site of serine 262 (I-G-S(p)-T-E), according to the protein MAPT.

Actions biochimiques/physiologiques

Removal of MAPT (microtubule associated protein tau) results in developmental delay and learning disability. It participates in the pathology of Alzheimer′s disease (AD). It helps in the assembly and maintenance of microtubule structure

Caractéristiques et avantages

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Description de la cible

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Forme physique

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable