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SAB4200039

Sigma-Aldrich

Anti-Serotonin Transporter (N-terminal) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-5-hydroxytryptamine transporter, Anti-5HTT, Anti-HTT, Anti-OCD1, Anti-SERT, Anti-SLC6A4 solute carrier family 6, member 4

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen ~83 kDa

Espèces réactives

human

Concentration

~1.5 mg/mL

Technique(s)

western blot: 1.5-3.0 μg/mL using SH-SY5Y cell lysates

Numéro d'accès UniProt

P31645

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

rat ... Slc6a4(25553)

Description générale

Solute carrier family 6 member 4 (SLC6A4), also known as 5-hydroxytryptamine transporter (5-HTT), is an integral membrane protein, encoded by the gene mapped to human chromosome 17q11.2. The encoded protein is a member of SLC6 gene family and is mainly expressed in brain and blood cells.

Application

Anti-Serotonin Transporter (N-terminal) antibody produced in rabbit has been used in western blot analysis and immunohistochemistry.

Actions biochimiques/physiologiques

Solute carrier family 6 member 4 (SLC6A4) catalyzes the transport of neurotransmitter serotonin from the synaptic space into presynaptic neurons. It also plays a vital role in mood and anxiety regulation. Mutation on the gene might alter the expression of serotonin (5HT) in the synaptic cleft, which ultimately leads to schizophrenia. Allelic variations in the gene increases the risk of susceptibility to autism and rigid-compulsive behaviors.
The polymorphic promoter region of the serotonin transporter gene serotonin-transporter-linked polymorphic region (5HTTLPR), has been suggested to affect serotonin uptake and may play a role in the pathogenesis of depression, obsessive-compulsive disorder (OCD) and aggressive behavior.

Forme physique

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Epigenetic changes of serotonin transporter in the patients with alcohol dependence: methylation of an serotonin transporter promoter CpG island.
Park BY
Psychiatry Investigation, 8, 130-133 (2011)
Elevation of cortical serotonin transporter activity upon peripheral immune challenge is regulated independently of p38 mitogen-activated protein kinase activation and transporter phosphorylation.
Schwamborn R, et.al.
Journal of Neurochemistry, 137, 423-435 (2016)
Fluoxetine Increases the Expression of miR-572 and miR-663a in Human Neuroblastoma Cell Lines
Mundalil Vasu M
PLoS ONE, 11 (2016)
Mahesh Mundalil Vasu et al.
PloS one, 11(10), e0164425-e0164425 (2016-10-08)
Evidence suggests neuroprotective effects of fluoxetine, a selective serotonin reuptake inhibitor (SSRI), on the developed neurons in the adult brain. In contrast, the drug may be deleterious to immature or undifferentiated neural cells, although the mechanism is unclear. Recent investigations
Robert Schwamborn et al.
Journal of neurochemistry, 137(3), 423-435 (2016-03-01)
The serotonin transporter (SERT) is responsible for high-affinity serotonin (5-HT) uptake from extracellular fluid and is a prominent pharmacological target in the treatment of depression. In recent years, depression has also been linked to immune system activation. Inflammatory conditions can
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