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SAB2500950

Sigma-Aldrich

Anti-SLC6A4/5HTT/SERT antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-HGNC:11050, Anti-SERT

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About This Item

Numéro MDL:
MFCD01634174
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

goat

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

human

Technique(s)

indirect ELISA: suitable
western blot: suitable

Numéro d'accès UniProt

P31645

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... SLC6A4(6532)

Description générale

Solute carrier family 6 member 4 (SLC6A4), also known as 5-hydroxytryptamine transporter (5-HTT), is an integral membrane protein, encoded by the gene mapped to human chromosome 17q11.2. The encoded protein is a member of SLC6 gene family and is mainly expressed in brain and blood cells.

Immunogène

Peptide with sequence C-LHQGERETWGK from the internal region of the protein sequence according to NP_001036.1.

Application

Anti-SLC6A4/5HTT/SERT antibody produced in goat has been used in immunolabelling and Western blotting.

Actions biochimiques/physiologiques

Solute carrier family 6 member 4 (SLC6A4) catalyzes the transport of neurotransmitter serotonin from the synaptic space into presynaptic neurons. It also plays a vital role in mood and anxiety regulation. Mutation on the gene might alter the expression of serotonin (5HT) in the synaptic cleft, which ultimately leads to schizophrenia. Allelic variations in the gene increase the risk of susceptibility to autism and rigid-compulsive behaviors.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319

Conseils de prudence

P305 + P351 + P338

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Allelic Heterogeneity at the Serotonin Transporter Locus (SLC6A4) Confers Susceptibility to Autism and Rigid-Compulsive Behaviors
James S
Academic Journal of Interdisciplinary Studies (2005)
Linkage mapping of serotonin transporter protein gene SLC6A4
on chromosome 17
J. Gelernter
Human Genetics (2005)
miR-15a and miR-16 regulate serotonin transporter expression in human placental and rat brain raphe cells
Pablo R
The International Journal of Neuropsychopharmacology (2013)
Pablo R Moya et al.
The international journal of neuropsychopharmacology, 16(3), 621-629 (2012-05-09)
The serotonin transporter (SERT) is a key regulatory molecule in serotonergic transmission implicated in numerous biological processes relevant to human disorders. Recently, it was shown that SERT expression is controlled by miR-16 in mouse brain. Here, we show that SERT
Nadia Postupna et al.
The American journal of pathology, 187(4), 884-895 (2017-02-19)
Cognitive impairment in older individuals is a complex trait that in population-based studies most commonly derives from an individually varying mixture of Alzheimer disease, Lewy body disease, and vascular brain injury. We investigated the molecular composition of synaptic particles from
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