S6256

Sulfamethazine

99.0-101.0% (on dried basis)

• Synonyme(s) : 4,6-Dimethylsulfadiazine, 4-Amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide, Sulfadimethyldiazine, Sulfadimidine
• Formule empirique (notation de Hill) : C₁₂H₁₄N₄O₂S
• Numéro CAS: 57-68-1
• Poids moléculaire : 278.33
• Beilstein: 261304
• Numéro CE : 200-346-4
• Numéro MDL: MFCD00006066
• Code UNSPSC : 51284910
• ID de substance PubChem : 24899686
• Nomenclature NACRES : NA.85

Propriétés

• Niveau de qualité: 200
• Essai: 99.0-101.0% (on dried basis)
• Forme: powder or crystals
• Conditions de stockage: (Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
• Couleur: white to off-white
• Spectre d'activité de l'antibiotique: Gram-negative bacteria; Gram-positive bacteria
• Mode d’action: DNA synthesis | interferes; enzyme | inhibits
• Température de stockage: 2-8°C
• Chaîne SMILES: Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1
• InChI: 1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16)
• Clé InChI: ASWVTGNCAZCNNR-UHFFFAOYSA-N

Description

Description générale

Chemical structure: sulfonamide

Application

Sulfamethazine is an antibiotic used to treat bronchitis, prostatitis and urinary tract infections[1]. It is used in disposition and depletion kinetic studies[2][3]. It is used to develop detection techniques for quantification in fluids such as cows′ milk, honey and swine urine[4].

Actions biochimiques/physiologiques

An antimicrobial sulfur drug. Induces CYP3A4 expression and acetylated by N-acetyltransferase. Exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11.

Sulfamethazine is an antimicrobial sulfur drug that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfamethazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid[1]. It induces CYP3A4 expression and is acetylated by N-acetyltransferase. It exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11. Sulfamethazine is bacteriostatic.

Conditionnement

25G,100G

Autres remarques

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)