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R9157

Sigma-Aldrich

Ro 4-1284

≥98% (HPLC)

Synonyme(s) :

2-Hydroxy-2-ethyl-3-isobutyl-9,10-dimethoxy-1,2,3,4,5,6,7-hexahydrobenzo[a]chinolizine

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About This Item

Formule empirique (notation de Hill):
C21H33NO3
Numéro CAS:
303-75-3
Poids moléculaire :
347.49
Numéro MDL:
MFCD01663028
Code UNSPSC :
12352200
ID de substance PubChem :
329824045

Pureté

≥98% (HPLC)

Forme

solid

Solubilité

DMSO: 16 mg/mL

Auteur

Roche

Température de stockage

2-8°C

Chaîne SMILES 

CCC1(O)CC2N(CCc3cc(OC)c(OC)cc23)CC1CC(C)C

InChI

1S/C21H33NO3/c1-6-21(23)12-18-17-11-20(25-5)19(24-4)10-15(17)7-8-22(18)13-16(21)9-14(2)3/h10-11,14,16,18,23H,6-9,12-13H2,1-5H3

Clé InChI

TUNMGCULOKMBNJ-UHFFFAOYSA-N

Actions biochimiques/physiologiques

Ro 4-1284 is a reversible VMAT2 inhibitor.

Caractéristiques et avantages

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogrammes

Environment
GHS09

Mention d'avertissement

Warning

Mentions de danger

H400

Conseils de prudence

P273

Classification des risques

Aquatic Acute 1

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

M E Maragoudakis et al.
Microvascular research, 50(2), 215-222 (1995-09-01)
A method providing a biochemical index for the evaluation of promoters or inhibitors of angiogenesis in the chick chorioallantoic membrane (CAM) is here described and validated. This method is based on the determination of collagenous protein synthesis which takes place
M Q Paiva et al.
Naunyn-Schmiedeberg's archives of pharmacology, 348(5), 466-471 (1993-11-01)
The aim of the present work was to study the influence of tissue morphological characteristics on the neuronal release (and by inference the distribution) of tritiated and endogenous noradrenaline. Rat vas deferens and dog spleen capsule were loaded with 0.2
S Yehuda et al.
European journal of pharmacology, 365(1), 27-34 (1999-02-13)
Ro4-1284 (2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-2H-benzo[a] quinolizin-2-ol hydrochloride), a benzoquinolizine, is a potent dopamine depletion agent whose acute and chronic administration results in a (1) deterioration of learning in the Morris Water Maze and passive avoidance tasks, (2) decrease in locomotion and rearing, (3)
M E Maragoudakis et al.
Kidney international, 43(1), 147-150 (1993-01-01)
Basement membrane (BM) exerts profound influence on endothelial cell (EC) behavior. In addition BM is a structural element of blood vessels; in fact at some point of their formation blood vessels are bare EC tubes lined with the BM produced
J E Leysen et al.
European journal of pharmacology, 206(1), 39-45 (1991-01-25)
[3H]Ketanserin was found to label (besides a low amount of 5-HT2 receptors) non-serotonergic binding sites on human platelet membranes. The latter binding was detected in the presence of excess of the 5-HT2 antagonist BW501, and was potently inhibited by tetrabenazine.
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