R4632

Retinyl acetate

synthetic, crystalline solid or supercooled liquid

• Synonyme(s) : Acétate de rétinol
• Formule empirique (notation de Hill) : C₂₂H₃₂O₂
• Numéro CAS: 127-47-9
• Poids moléculaire : 328.49
• Beilstein: 1915439
• Numéro CE : 204-844-2
• Numéro MDL: MFCD00019413
• Code UNSPSC : 12352205
• eCl@ss : 34058009
• ID de substance PubChem : 57654592
• Nomenclature NACRES : NA.79

Propriétés

• Source biologique: synthetic
• Essai: ≥90% (HPLC)
• Forme: crystalline solid or supercooled liquid
• Puissance: 2,600,000-2,940,000 I.U. per g
• Couleur: light yellow to dark yellow
• Pf: 57-58 °C; ~58 °C (lit.)
• Température de stockage: −20°C
• Chaîne SMILES: CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(C)=O)C(C)(C)CCC1
• InChI: 1S/C22H32O2/c1-17(9-7-10-18(2)14-16-24-20(4)23)12-13-21-19(3)11-8-15-22(21,5)6/h7,9-10,12-14H,8,11,15-16H2,1-6H3/b10-7+,13-12+,17-9+,18-14+
• Clé InChI: QGNJRVVDBSJHIZ-QHLGVNSISA-N

Description

Description générale

Vitamin A usually occurs in food as retinyl esters,[1] which are the pre-formed sources of vitamin A.[2] Retinyl acetate exists as yellow crystals and is insoluble in water. It is soluble in ethanol and oils.[3]

Application

Retinyl acetate has been used:

• to study its effects on cochlear development in mice[4]
• as a component of an internal standard to quantify antioxidants in yolk[4]
• as an internal standard to determine serum retinol concentration[5]

Actions biochimiques/physiologiques

Retinal, retinol and retinoic acid are the aldehyde, alcohol and acid forms of vitamin A. The retinoids exist as many geometric isomers due to the unsaturated bonds in the aliphatic chain.
Retinoids also exist as retinyl esters such as retinyl propionate, retinyl acetate and retinyl palmitate. Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as needed. Retinyl acetate is used in a wide range of biological applications.

Forme physique

Packaged as a melt and may exist as a crystalline solid or a supercooled viscous liquid

Remarque sur l'analyse

Activity based on HPLC comparison to USP standard.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H360D,H413
• Conseils de prudence: P202 - P273 - P280 - P308 + P313 - P405 - P501
• Classification des risques: Aquatic Chronic 4 - Repr. 1B
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type ABEK (EN14387) respirator filter