P1382

Phenoxymethylpenicillinic acid potassium salt

potency: 1444-1536 units per mg

• Synonyme(s) : Penicillin V potassium salt
• Formule empirique (notation de Hill): C₁₆H₁₇N₂O₅SK
• Poids moléculaire : 388.48
• Numéro CE : 205-086-5
• Numéro MDL: MFCD00051771
• Code UNSPSC : 12352106
• ID de substance PubChem : 24898194
• Nomenclature NACRES : NA.85

Propriétés

• Forme: solid
• Puissance: 1444-1536 units per mg
• Spectre d'activité de l'antibiotique: Gram-positive bacteria
• Mode d’action: cell wall synthesis | interferes
• Chaîne SMILES: [K+].CC1(C)S[C@@H]2[C@H](NC(=O)COc3ccccc3)C(=O)N2[C@H]1C([O-])=O
• InChI: 1S/C16H18N2O5S.K/c1-16(2)12(15(21)22)18-13(20)11(14(18)24-16)17-10(19)8-23-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1
• Clé InChI: HCTVWSOKIJULET-LQDWTQKMSA-M

Description

Description générale

Chemical structure: ß-lactam

Application

Phenoxymethylpenicillinic acid, also known as Penicillin V, is a narrow spectrum antibiotic used to treat mild to moderate infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered orally. Penicillin V is a penicillin β-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. It is commonly used in cell culture in combination with streptomcyin and other antibiotics. It is used to study penicillin-binding protein 2, molecular cloning of the Bacillus sphaericus penicillin V amidase gene, and gastrointestinal persistence and bile tolerance of Listeria monocytogenes.

Actions biochimiques/physiologiques

Phenoxymethylpenicillinic acid binds to specific penicillin-binding proteins (PBPs) and inhibits the synthesis of bacterial cell walls by preventing cell wall peptidoglycan chain cross-linking. This causes cell lysis, which is mediated by autolytic enzymes such as autolysins. Phenoxymethylpenicillnic acid may interfere with autolysin inhibitors.

Autres remarques

10mu,100mu

Keep container tightly closed in a dry and well-ventilated place.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H302,H317,H334
• Conseils de prudence: P280 - P301 + P312 + P330 - P302 + P352
• Classification des risques: Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable