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Documents

P1138

Sigma-Aldrich

1,2-Distearoyl-sn-glycero-3-phosphocholine

≥99%

Synonyme(s) :

PC, 1,2-Dioctadecanoyl-sn-glycero-3-phosphocholine, 3-sn-Phosphatidylcholine, 1,2-distearoyl, L-α-Phosphatidylcholine, distearoyl, L-β,γ-Distearoyl-α-lecithin, DSPC, PC(18:0/18:0)

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About This Item

Formule empirique (notation de Hill):
C44H88NO8P
Numéro CAS:
816-94-4
Poids moléculaire :
790.15
Numéro Beilstein :
3923978
Numéro CE :
212-440-2
Numéro MDL:
MFCD00036905
Code UNSPSC :
12352211
ID de substance PubChem :
24898160
Nomenclature NACRES :
NA.25

Source biologique

semisynthetic

Pureté

≥99%

Forme

powder

Groupe fonctionnel

phospholipid

Type de lipide

phosphoglycerides

Conditions d'expédition

ambient

Température de stockage

−20°C

Chaîne SMILES 

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O

InChI

1S/C44H88NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h42H,6-41H2,1-5H3/t42-/m1/s1

Clé InChI

NRJAVPSFFCBXDT-HUESYALOSA-N

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Description générale

Non-pyrogenic, well-defined liposomes, loaded with a molecule of choice, are formed by a single hydration step.

Application


  • Amantadine interactions with phase separated lipid membranes.: This study explores the interactions between amantadine and phase-separated lipid membranes, providing insights into the role of 1,2-Distearoyl-sn-glycero-3-phosphocholine in membrane structure and function (Kinnun et al., 2024).

  • Design of charge converting lipid nanoparticles via a microfluidic coating technique.: This research designs lipid nanoparticles with charge-converting capabilities using 1,2-Distearoyl-sn-glycero-3-phosphocholine, enhancing drug delivery systems (Zöller et al., 2024).

  • Investigation and Comparison of Active and Passive Encapsulation Methods for Loading Proteins into Liposomes.: The study compares methods for protein encapsulation into liposomes using 1,2-Distearoyl-sn-glycero-3-phosphocholine, advancing drug delivery technologies (Pisani et al., 2023).

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Pan Li et al.
Journal of controlled release : official journal of the Controlled Release Society, 162(2), 349-354 (2012-07-18)
Ultrasound targeted microbubble destruction (UTMD) was one of the most promising strategies to enhance drug delivery in cancer therapy. Microbubbles (MBs) serve as a vehicle to carry anti-tumor drugs and locally release them when exposed to therapeutic ultrasound, resulting in
Peter J Kueffer et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(16), 6512-6517 (2013-03-29)
The application of boron neutron capture therapy (BNCT) following liposomal delivery of a (10)B-enriched polyhedral borane and a carborane against mouse mammary adenocarcinoma solid tumors was investigated. Unilamellar liposomes with a mean diameter of 134 nm or less, composed of
Sweta Modi et al.
Journal of controlled release : official journal of the Controlled Release Society, 162(2), 330-339 (2012-07-18)
Nanoparticulate drug carriers such as liposomal drug delivery systems are of considerable interest in cancer therapy because of their ability to passively accumulate in solid tumors. For liposomes to have practical utility for antitumor therapy in patients, however, optimization of
Mette Marie Bruun Nielsen et al.
Langmuir : the ACS journal of surfaces and colloids, 29(5), 1525-1532 (2013-01-04)
Imaging ellipsometry (IE) has been applied to generate laterally resolved thickness maps of spin-coated membranes in both the dry and fully hydrated state. Spin-coating offers a convenient preparation method for stacked supported membranes, and in-depth thickness maps for such films
Hiroyuki Nakamura et al.
Organic & biomolecular chemistry, 10(7), 1374-1380 (2011-12-24)
The fluorescence-labeled closo-dodecaborane lipid (FL-SBL) was synthesized from (S)-(+)-1,2-isopropylideneglycerol as a chiral starting material. FL-SBL was readily accumulated into the PEGylated DSPC liposomes prepared from DSPC, CH, and DSPE-PEG-OMe by the post insertion protocol. The boron concentrations and the fluorescent
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