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P0424

Sigma-Aldrich

Prostaglandin F2α tris salt

≥99%, synthetic, powder

Synonyme(s) :

(5Z,9α,11α,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dienoic acid tris salt, PGF2α−Tris

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About This Item

Formule empirique (notation de Hill):
C20H34O5 · C4H11NO3
Numéro CAS:
38562-01-5
Poids moléculaire :
475.62
Numéro Beilstein :
4087514
Numéro CE :
254-002-3
Numéro MDL:
MFCD00077863
Code UNSPSC :
12352401
eCl@ss :
42020658
ID de substance PubChem :
24898103
Nomenclature NACRES :
NA.77

Source biologique

synthetic

Pureté

≥99%

Forme

powder

Couleur

white

Solubilité

H2O: 1 mg/mL
ethanol: 50 mg/mL

Groupe fonctionnel

carboxylic acid
hydroxyl

Conditions d'expédition

ambient

Température de stockage

−20°C

Chaîne SMILES 

NC(CO)(CO)CO.[H][C@]1(C\C=C/CCCC(O)=O)[C@@H](O)C[C@@H](O)[C@]1([H])\C=C\[C@@H](O)CCCCC

InChI

1S/C20H34O5.C4H11NO3/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25;5-4(1-6,2-7)3-8/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25);6-8H,1-3,5H2/b7-4-,13-12+;/t15-,16+,17+,18-,19+;/m0./s1

Clé InChI

IYGXEHDCSOYNKY-RZHHZEQLSA-N

Informations sur le gène

human ... PTGFR(5737)

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Description générale

Aqueous solutions are stable for 30 days at 2-8°C and for several months frozen at −0°C in single use aliquots. Avoid repeated freeze/thaw cycles.

Actions biochimiques/physiologiques

Luteolytic prostaglandin that induces parturition. Potent vasoconstrictor of pulmonary, coronary, and cerebral arteriole beds. A positive feedback loop between endometrial PG F2α and luteal oxytocin is responsible for completion of luteolysis.
Luteolytic prostaglandin that induces parturition. Potent vasoconstrictor of pulmonary, coronary, and cerebral arteriole beds. Also stimulates contraction of smooth muscle, such as in bronchi, with possible involvement in asthma. This effect is at least partially mediated through tachykinin release.

Pictogrammes

Health hazardExclamation mark
GHS08,GHS07

Mention d'avertissement

Danger

Mentions de danger

H302,H360FD

Classification des risques

Acute Tox. 4 Oral - Repr. 1B

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

J B Salom et al.
European journal of pharmacology, 203(1), 33-39 (1991-10-02)
We examined the effects of extracellular Ca2+ withdrawal and of Ca2+ entry blockers on goat cerebrovascular responses to prostaglandin F2 alpha (PGF2 alpha). We measured isometric tension in isolated middle cerebral arteries, and cerebral blood flow (CBF) in unanesthetized animals.
A R Fuchs
Journal of steroid biochemistry, 27(4-6), 1073-1080 (1987-01-01)
The oxytocin-neurophysin gene is expressed in several nontraditional sites within the endocrine system. In the ovary its expression in the corpora lutea is initiated by ovulation. Ovarian oxytocin concentrations reach maximal levels around day 11 of luteal cycle and fall
J W Barnard et al.
Journal of applied physiology (Bethesda, Md. : 1985), 72(6), 2469-2474 (1992-06-01)
To characterize the interactions between prostaglandin F2 alpha and prostacyclin in controlling tone in the pulmonary circulation, isolated rat lungs were ventilated, perfused with blood, and subjected to challenge by prostaglandin F2 alpha in increasing doses. The pulmonary resistance was
W Wuttke et al.
Steroids, 63(5-6), 299-305 (1998-06-10)
During the second half of the luteal phase, the human corpus luteum becomes responsive to regular luteinizing hormone (LH) pulses. These LH pulses stimulate progesterone secretion tonically, and during this tonic stimulation, additional LH-independent progesterone pulses occur, which are particularly
A Gogny et al.
Theriogenology, 74(9), 1531-1538 (2010-08-17)
The aim of this in vitro study was to compare the uterokinetic activity of oxytocin and dinoprost, the natural PGF2α, with or without aglepristone, in canine myometrial fibers. Thirty-three bitches were allocated into one of four groups, depending on their
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