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N6803

Sigma-Aldrich

Nystatin water soluble

powder, suitable for cell culture

Synonyme(s) :

Nystatin Solution

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About This Item

Code UNSPSC :
12352207
Nomenclature NACRES :
NA.76

product name

Nystatin water soluble, suitable for cell culture

Source biologique

synthetic

Forme

powder

Poids mol.

1029.23 g/mol

Technique(s)

cell culture | mammalian: suitable

Solubilité

100 mg/mL

Conditions d'expédition

dry ice

Température de stockage

−20°C

Catégories apparentées

Description générale

Nystatin is a polyene, broad-spectrum antibiotic. It can modify the microstructure of lipid rafts and sequestrate cholesterol present on the cell membrane of eukaryotes. Thus, nystatin can modulate immune responses. This is carried out through cytokine signaling, activation of lymphocytes and pathogen recognition.
Molecular Formula: C51H84N2O19
Molecular Weight: 1029.23
Nystatin water soluble is a Nystatin derivate with fungistatic and fungicidal activity in resemblance to Nystatin. However, as opposed to the poor solubility of Nystatin the water soluble derivate can be dissolved in concentration of up to 100mg/ml. Nystatin binds to ergosterol which increases cell membrane permeability in sensitive fungi. Nystatin is mainly clinically active against Candida species. However, it is also reported to be effective against Aspergillus, Coccidioides immitis, Cryptococcus neoformans, Histoplasma capsulatum, Blastomyces dermatidis, and other yeasts and fungi. Nystatin has also been used to enrich mutants by negative selection in yeasts. The minimum inhibitory concentration (MIC) of Nystatin to Saccharomyces cerevisiae was reported to be 3μg/ml while for clinical isolates of Candida albicans the MIC was reported to be 4-16μg/ml.

Autres remarques

Technical data

  • Nystatin water soluble is a fully solubilized powder of Nystatin with potency of ≥2000 units/mg according to USP standard.
  • Nystatin water soluble is 0.2μm filtered and endotoxin free.
  • The suggest working concentration of Nystatin water soluble is 100 units/ml.
  • It is recommended to store solutions of Nystatin water soluble in the dark.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Water-Soluble Nystatin and Derivative
Aviran Amir, Michal Levin-Khalifa, and Tamar Dvash
ACS Medicinal Chemistry Letters, 182?187-182?187 (2022)
Nystatin enhances the immune response against Candida albicans and protects the ultrastructure of the vaginal epithelium in a rat model of vulvovaginal candidiasis
Zhang X, et al.
BMC Microbiology, 18(1), 166-166 (2018)

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