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MAK184

Sigma-Aldrich

Succinate Colorimetric Assay Kit

Sufficient for 100 Colorimetric tests

Synonyme(s) :

Succinic Acid Assay Kit

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About This Item

Numéro CE :
205-778-7
Code UNSPSC :
12161503
Nomenclature NACRES :
NA.84

Application(s)

cosmetics
food and beverages

Méthode de détection

colorimetric

Maladie(s) pertinente(s)

cardiovascular diseases; immunological diseases

Température de stockage

−20°C

Description générale

Succinate (succinic acid) is a citric acid cycle intermediate and functions in the transport of electrons to the mitochondrial electron transport chain.[1][2] It also functions in innate immune signaling and induces IL-1β production during inflammation. Succinates have been often used for the treatment of hypertension.[3] Succinate measurements can be useful for studying its metabolic, immunological, and therapeutic activities.

Application

Succinate Colorimetric Assay Kit has been used to measure the concentration of succinate.[4][5]

Adéquation

Suitable for the detection of succinate in a variety of samples such as cell and tissue culture supernatants and in liquid samples such as wine.

Principe

The Succinate Colorimetric Assay Kit is a highly sensitive assay for determining succinate levels (ranging from 2-10 nmole/well) in a variety of samples. Succinate concentration is determined by a coupled enzyme reaction, which results in a colorimetric (450 nm) product proportional to the succinate present.

Composants de kit seuls

Réf. du produit
Description
  • Succinate Assay Buffer
  • Succinate Converter
  • Succinate Enzyme Mix
  • Succinate Substrate Mix
  • Succinate Developer
  • Succinate Standard

Pictogrammes

Health hazardCorrosion
GHS08,GHS05

Mention d'avertissement

Danger

Mentions de danger

H314,H334

Classification des risques

Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B

Code de la classe de stockage

8A - Combustible corrosive hazardous materials

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number
8G27K06490
7A21K06490
4C08K06490
4A18K06490
3B02K06490

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism.
Li J, et al.
Nature Communications, 8(1), 1322-1322 (2017)
DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism.
Shen J, et al.
JCI insight, 2(12) (2017)
Metoprolol succinate extended release/hydrochlorothiazide combination tablets.
Hainer JW and Jennifer S
Vascular Health, 3(3), 279-279 (2007)
Yurong Zhang et al.
Redox biology, 28, 101365-101365 (2019-11-11)
Though succinate accumulation is associated with reactive oxygen species (ROS) production and neuronal injury, which play critical roles in epilepsy, it is unclear whether succinate accumulation contributes to the onset of epilepsy or seizures. We sought to investigate changes in
Succinate, an intermediate in metabolism, signal transduction, ROS, hypoxia, and tumorigenesis.
Tretter L, et al.
Biochimica et Biophysica Acta - Bioenergetics, 1857(8), 1086-1101 (2016)
Afficher tous les articles scientifiques apparentés

Questions

1–2 of 2 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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