M9940
Mercaptoethylguanidine hemisulfate salt
≥98%
Synonyme(s) :
MEG hemisulfate salt
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About This Item
Formule linéaire :
H2NC(=NH)NHSCH2CH3 · 1/2 H2SO4
Numéro CAS:
Poids moléculaire :
168.23
Numéro MDL:
Code UNSPSC :
12352202
ID de substance PubChem :
Nomenclature NACRES :
NA.77
Produits recommandés
Essai
≥98%
Forme
solid
Conditions d'expédition
wet ice
Température de stockage
2-8°C
Chaîne SMILES
OS(O)(=O)=O.NC(=N)NCCS.NC(=N)NCCS
InChI
1S/2C3H9N3S.H2O4S/c2*4-3(5)6-1-2-7;1-5(2,3)4/h2*7H,1-2H2,(H4,4,5,6);(H2,1,2,3,4)
Clé InChI
XJKZAAUVINNNNC-UHFFFAOYSA-N
Application
Selective iNOS inhibitor and scavenger of peroxynitrite.
Actions biochimiques/physiologiques
Demonstrates potent antiinflammatory effects in an animal model of airway infection that mimics human cystic fibrosis.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
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David W Paquette et al.
Journal of periodontology, 77(3), 385-391 (2006-03-04)
Nitric oxide is a free radical produced in host tissues by constitutive and inducible forms of the enzyme nitric oxide synthase. Nitric oxide plays physiological roles, but it is also involved in the pathophysiology of several inflammatory conditions, including arthritis
K Soejima et al.
Burns : journal of the International Society for Burn Injuries, 27(8), 809-815 (2001-11-24)
This study tested the hypothesis that nitric oxide (NO) synthesized from inducible NO synthase (iNOS) is responsible for the cardiac dysfunction observed after burn and smoke inhalation injury. Twelve sheep received 40% third-degree burn and smoke inhalation under halothane anesthesia.
Ahmet Guven et al.
Renal failure, 30(7), 747-754 (2008-08-16)
Nitric oxide (NO) and peroxynitrite (OONO-) are implicated in the pathophysiology of renal ischemia/reperfusion (I/R). The aim of this study was to investigate and compare the efficiency of S-methylisothiourea (SMT), an iNOS inhibitor, and mercaptoethylguanidine (MEG), a scavenger of peroxynitrite
Mustafa Ozturk et al.
Journal of pineal research, 50(1), 89-96 (2010-11-11)
Doxorubicin (DOX) and Trastuzumab (TRAST) are effective agents for the treatment of many neoplastic diseases. Cardiotoxicity is a major side effect of these drugs and limit their use. In this study, the possible protective effects of melatonin (MEL), mercaptoethylguanidine (MEG)
Christian Kellner et al.
Cancer letters, 215(1), 43-52 (2004-09-18)
We investigated the early events involved in loss of mitochondrial membrane potential (DeltaPsi(mt)) leading to apoptosis in cells derived from patients with acute lymphocytic leukemia after exposure to phenolic antioxidants. Using the nitric oxide binding dye diaminofluorescein-FM diacetate, we found
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