M5750

Menadione sodium bisulfite

≥95% (TLC)

• Synonyme(s) : 2-Methyl-1,4-naphthoquinone sodium bisulfite
• Formule empirique (notation de Hill): C₁₁H₉NaO₅S
• Numéro CAS: 130-37-0
• Poids moléculaire : 276.24
• Numéro CE : 204-987-0
• Numéro MDL: MFCD00051456
• Code UNSPSC : 12352200
• ID de substance PubChem : 24897038
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: synthetic
• Niveau de qualité: 200
• Essai: ≥95% (TLC)
• Forme: powder
• Couleur: white to off-white
• Solubilité: H₂O: ≥50 mg/mL, clear, colorless to faintly yellow
• Application(s): cell analysis
• Auteur: Eli Lilly
• Température de stockage: −20°C
• Chaîne SMILES: [Na+].CC1(CC(=O)c2ccccc2C1=O)S([O-])(=O)=O
• InChI: 1S/C11H10O5S.Na/c1-11(17(14,15)16)6-9(12)7-4-2-3-5-8(7)10(11)13;/h2-5H,6H2,1H3,(H,14,15,16);/q;+1/p-1
• Clé InChI: XDPFHGWVCTXHDX-UHFFFAOYSA-M

Description

Application

Menadione sodium bisulfite has been used:

• as a priming agent in tomato for improving salt tolerance[1]
• to induce reactive oxygen species (ROS) in human lung epithelium BEAS-2B microtissues[2]
• to induce endogenous superoxide production in mouse C17.2 neural stem cells[3]

Actions biochimiques/physiologiques

Menadione sodium bisulfite is a water-soluble form of menadione, which belongs to the Vitamin K class of compounds. These are necessary for the biosynthesis of prothrombin and other blood clotting factors. Menadione is a prothrombogenic compound and is used as a model quinone in cell culture and in vivo investigations.

Menadione has been shown to affect gap-junctional intercellular communication by mediation of tyrosine phosphorylation. Menadione has demonstrated cytotoxic activity against a variety of cell lines and can induce apoptosis in cultured cells, such as osteoclasts and osteoblasts, via elevation of peroxide and superoxide radical levels.

An HPLC method for detection of menadione sodium bisulfite in multivitamin formulations has been published. A chemiluminescence assay for menadione sodium bisulfite in pharmaceutical preparations and biological fluids has been reported.

Caractéristiques et avantages

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Autres remarques

Water soluble vitamin K₃.

Informations sur la sécurité

• Pictogrammes: GHS07,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H410
• Conseils de prudence: P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Classification des risques: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves