L8912

L-Leucine

98.5-101.0%, suitable for cell culture, non-animal source, meets EP, JP, USP testing specifications

• Synonyme(s) : (S)-Leucine, (S)-2-Amino-4-methylpentanoic acid
• Formule linéaire : (CH₃)₂CHCH₂CH(NH₂)CO₂H
• Numéro CAS: 61-90-5
• Poids moléculaire : 131.17
• Numéro Beilstein : 1721722
• Numéro CE : 200-522-0
• Numéro MDL: MFCD00002617
• Code UNSPSC : 12352209
• eCl@ss : 32160406
• ID de substance PubChem : 24896510
• Nomenclature NACRES : NA.26

Propriétés

• product name: L-Leucine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%
• Source biologique: non-animal source
• Agence: USP/NF; meets EP testing specifications; meets JP testing specifications; meets USP testing specifications
• Pureté: 98.5-101.0%
• Forme: powder
• Activité optique: [α]20/D 14.9 to 16.0°, c = 4 in 6 M HCl; [α]25/D 14.9 to 17.3 °, c = 4 in 6 M HCl
• Qualité: meets EP, JP, USP testing specifications
• Technique(s): cell culture | mammalian: suitable
• Impuretés: endotoxin, tested
• Couleur: white
• Pf: >300 °C (lit.)
• Solubilité: 1 M HCl: 50 mg/mL
• Traces de cations: As: ≤1 ppm; Fe: ≤10 ppm; NH₄⁺: <0.02%; heavy metals: ≤10 ppm
• Application(s): peptide synthesis; pharmaceutical (small molecule)
• Groupe fonctionnel: amine; carboxylic acid
• Température de stockage: room temp
• Chaîne SMILES: CC(C)C[C@H](N)C(O)=O
• InChI: 1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1
• Clé InChI: ROHFNLRQFUQHCH-YFKPBYRVSA-N

Description

Description générale

Leucine is a non-glucogenic, and essential amino acid. It is a branched-chain amino acid that is a structural component of proteins.

Application

L-Leucine has been used:

• as a hypertrophic agent to monitor its effects on myotubes.
• as a component of PMG media for culturing yeast.
• in myotube protein synthesis analysis in skeletal muscle cells.
• to study its effects on hepatic lipid metabolism.

Actions biochimiques/physiologiques

Leucine plays a role in intracellular signaling, gene transcription, and translation. It promotes the synthesis of protein by activating the mammalian target of the rapamycin (mTOR) signaling pathway in placental cells, skeletal muscles, and adipose tissue. Leucine inhibits protein degradation and promotes mitochondrial biogenesis, glucose metabolism, and fatty acid oxidation to provide energy for protein synthesis.

Autres remarques

For additional information on our range of Biochemicals, please complete this form.

The product is intended for laboratory use only, and it is not suitable for drug, household, or other purposes.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)