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L8170

Sigma-Aldrich

Pseudolaric Acid B

≥98% (HPLC)

Synonyme(s) :

(-)-Pseudolaric acid B, O-Acetylpseudolaric acid C, Pseudolarix acid B

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About This Item

Formule empirique (notation de Hill):
C23H28O8
Numéro CAS:
82508-31-4
Poids moléculaire :
432.46
Numéro MDL:
MFCD26960905
Code UNSPSC :
12352106
Nomenclature NACRES :
NA.25

Source biologique

Larix kaempferi

Pureté

≥98% (HPLC)

Forme

powder or crystals

Conditions de stockage

protect from light

Couleur

white to off-white

Solubilité

methanol: 1 mg/mL, clear, colorless

Application(s)

metabolomics
vitamins, nutraceuticals, and natural products

Température de stockage

2-8°C

Chaîne SMILES 

O=C(OC)C1=CC[C@@]2(C(O[C@@](/C=C/C=C(C(O)=O)\C)(C)[C@@H]3CC2)=O)[C@]3(OC(C)=O)CC1

InChI

1S/C23H28O8/c1-14(17(24)25)6-5-10-21(2)16-9-12-22(19(27)31-21)11-7-15(18(26)29-3)8-13-23(16,22)20(28)30-4/h5-7,10,16H,8-9,11-13H2,1-4H3,(H,24,25)/b10-5+,14-6+/t16-,21+,22+,23+/m0/s1

Clé InChI

XRLYZNSOXNPKOR-CBDALDGHSA-N

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Actions biochimiques/physiologiques

Pseudolaric acid B, a natural diterpenoid compound, is isolated from Pseudolarix kaempferi. It has shown antifungal, antifertility, and antiangiogenic properties. It also may exihibit anti-cancer and anti-inflammatory properties.

Pictogrammes

Skull and crossbonesHealth hazard
GHS06,GHS08

Mention d'avertissement

Danger

Mentions de danger

H301,H361fd

Conseils de prudence

P201 - P301 + P310 + P330

Classification des risques

Acute Tox. 3 Oral - Repr. 2

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Pauline Chiu et al.
Natural product reports, 27(7), 1066-1083 (2010-04-21)
The pseudolaric acids are diterpenoids isolated from the root bark of Pseudolarix amabilis, or the golden larch. Pseudolaric acids A and B are the major antifungal and anti-angiogenic congeners of this family of compounds. This review presents the results of
Xia Mai et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(22), 3467-3471 (2013-02-05)
To study the effect of pseudolaric acid B (PLAB) on cell proliferation and cycle of human prostate carcinoma DU-145 cells. method: Its inhibitory effect on the cell growth was measured by MTT method. Characteristics of cell death were determined by
Tan Li et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 45(5), 668-676 (2012-01-24)
Pseudolaric acid B (PAB) is a novel diterpenoid, isolated from Pseudolarix kaempferi Gorden, which roots are widely used to treat inflammatory and microbial skin diseases for centuries, but the underlying mechanism remains elusive. To address the immunoregulatory mechanisms of PAB
Dandan Zhao et al.
Toxicology in vitro : an international journal published in association with BIBRA, 26(4), 595-602 (2012-03-06)
Pseudolaric acid B (PAB), a natural diterpene acid present in the traditional Chinese medicinal herb Tu-Jin-Pi, exerted anticancer effects on various cancer cells. However, the effect of PAB on DU145 cells, an in vitro model of hormone-refractory prostate cancer (HRPC)
Jing-hua Yu et al.
Acta pharmacologica Sinica, 29(9), 1069-1076 (2008-08-23)
To investigate the apoptotic mechanism of pseudolaric acid B (PAB) in human breast cancer MCF-7 cells. 3-(4,5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide analysis and morphological changes were applied to detect apoptosis. The percentage of apoptotic and necrotic cells were calculated by the lactate
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