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I8907

Sigma-Aldrich

Interferon β from rat

≥95%, recombinant, expressed in CHO cells, lyophilized powder, suitable for cell culture

Synonyme(s) :

IFN-β

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About This Item

Numéro MDL:
MFCD04040885
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

Source biologique

rat

Niveau de qualité

200

Produit recombinant

expressed in CHO cells

Pureté

≥95%

Forme

lyophilized powder

Poids mol.

~20 kDa

Conditionnement

pkg of 1 vial

Concentration

≥100000 units/mL

Technique(s)

cell culture | mammalian: suitable

Numéro d'accès UniProt

P70499

Conditions d'expédition

dry ice

Température de stockage

−70°C

Informations sur le gène

rat ... Ifnb1(24481)

Catégories apparentées

Actions biochimiques/physiologiques

Interferon β belongs to the type 1 interferon family pf proteins. It is also needed for the inhibition of tumor cell growth via cell death, S-phase increase and mediating differentiation. It is also important for bone homeostasis.
Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities.

Forme physique

Lyophilized from phosphate buffered saline (PBS) containing 125 mM trehalose.

Remarque sur l'analyse

The biological activity is determined in the cytopathic effect inhibition assay using rat epithelial-like (RATEC) cells with vesicular stomatitis virus (VSV). The cytopathic effect of 50% is produced with approximately 1 unit/ml interferon. Since there is no international rat interferon β standard, units are determined with respect to the NIH international standard reference for mouse interferon α/β.

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

C Ren et al.
Gene therapy, 15(21), 1446-1453 (2008-07-04)
Cell-based therapy for cancer is a promising new field. Among cell types that can be used for this purpose, mesenchymal stem cells (MSCs) appear to hold great advantage for reasons including easier propagation in culture, possible genetic modification to express
R B Pepinsky et al.
The Journal of pharmacology and experimental therapeutics, 297(3), 1059-1066 (2001-05-18)
Interferon therapies suffer from a relatively short half-life of the products in circulation. To address this issue we investigated the effects of polyethylene glycol modification (PEGylation) on the pharmacokinetic properties of human interferon (IFN)-beta-1a. PEGylation with a linear 20-kDa PEG
J Adriaansen et al.
Human gene therapy, 17(10), 985-996 (2006-09-21)
Interferon (IFN)-beta has significant immunomodulatory properties and has received much interest as a potentially therapeutic agent for rheumatoid arthritis (RA). Systemic IFN-beta treatment of patients with RA was not effective, probably because of pharmacokinetic issues. Therefore, we studied the effect
Junqiang Ye et al.
PloS one, 6(6), e20681-e20681 (2011-06-17)
The production of type I interferons (IFNs) in response to viral infections is critical for antiviral immunity. However, IFN production is transient, and continued expression can lead to inflammatory or autoimmune diseases. Thus, understanding the mechanisms underlying the negative regulation
Interferon standards and general abbreviations.
S Pestka
Methods in enzymology, 119, 14-23 (1986-01-01)
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