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G8923

Sigma-Aldrich

GANT58

≥98% (HPLC)

Synonyme(s) :

2,3,4,5-Tetra(4-pyridyl)thiophene, 4,4′,4′′,4′′′-Thiene-2,3,4,5-tetrayltetrapyridine

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About This Item

Formule empirique (notation de Hill):
C24H16N4S
Numéro CAS:
64048-12-0
Poids moléculaire :
392.48
Numéro MDL:
MFCD01103196
Code UNSPSC :
51111800
ID de substance PubChem :
329799981
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Couleur

white to pale yellow

Solubilité

DMSO: >10 mg/mL

Température de stockage

2-8°C

Chaîne SMILES 

c1cc(ccn1)-c2sc(-c3ccncc3)c(-c4ccncc4)c2-c5ccncc5

InChI

1S/C24H16N4S/c1-9-25-10-2-17(1)21-22(18-3-11-26-12-4-18)24(20-7-15-28-16-8-20)29-23(21)19-5-13-27-14-6-19/h1-16H

Clé InChI

USWLOKMMUTWFMD-UHFFFAOYSA-N

Actions biochimiques/physiologiques

GANT58 is a Hedgehog signaling pathway inhibitor. GANT58 inhibits the hedgehog signaling pathway downstream of Smo. GANT58 inhibits Gli transcriptional activity, and reduces cellular levels of the Hh pathway components Gli1, Shh, and patched.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Alessandra Ciucci et al.
PloS one, 8(3), e60145-e60145 (2013-04-05)
Recent evidence links aberrant activation of Hedgehog (Hh) signaling with the pathogenesis of several cancers including medulloblastoma, glioblastoma, melanoma as well as pancreas, colorectal, and prostate carcinomas. Here we investigated the role of the transcription factor Gli1 in ovarian cancer.
Andreas Frøslev Mathisen et al.
Scientific reports, 14(1), 14669-14669 (2024-06-26)
Non-obese diabetes (NOD) mice are an established, spontaneous model of type 1 diabetes in which diabetes develops through insulitis. Using next-generation sequencing, coupled with pathway analysis, the molecular fingerprint of early insulitis was mapped in a cohort of mice ranging
Uma Thanigai Arasu et al.
Cellular and molecular life sciences : CMLS, 77(20), 4093-4115 (2019-12-11)
Intercellular communication is fundamental to the survival and maintenance of all multicellular systems, whereas dysregulation of communication pathways can drive cancer progression. Extracellular vesicles (EVs) are mediators of cell-to-cell communication that regulate a variety of cellular processes involved in tumor
Li Ma et al.
Bone, 123, 176-188 (2019-04-01)
Chondrocyte proliferation and differentiation are crucial for endochondral ossification and strictly regulated by numerous signaling molecules and transcription factors, but the hierarchical regulatory network remains to be deciphered. The present study emphasized the interplay of Activin A, Foxa, Notch and
Shen Gu et al.
Biochemical and biophysical research communications, 533(4), 770-778 (2020-09-30)
Microcystin-leucine-arginine (MC-LR), produced by cyanobacteria, accumulates in the liver through blood circulation. We investigated the impact of MC-LR on liver fibrosis. Mice received a daily injection of MC-LR at various concentrations for 14 consecutive days aa and then mouse liver
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