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E1518

Sigma-Aldrich

Echistatin from Echis carinatus

lyophilized powder, γ-irradiated, BioXtra

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About This Item

Numéro CAS:
129038-42-2
Numéro MDL:
MFCD00081572
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.75

Source biologique

Echis carinatus

Niveau de qualité

200

Stérilité

γ-irradiated

Gamme de produits

BioXtra

Pureté

>95% (SDS-PAGE)

Forme

lyophilized powder

Poids mol.

5.2-5.4 kDa

Conditionnement

pkg of 50 μg

Technique(s)

cell culture | mammalian: suitable

Solubilité

water: soluble 0.1 mg/mL, clear, colorless

Conditions d'expédition

ambient

Température de stockage

−20°C

Clé InChI

XLBBKEHLEPNMMF-SSUNCQRMSA-N

Description générale

Echistatin is a small peptide disintegrin that has no multiple epitopes. It is a single chain polypeptide with a molecular mass of 5400. Echistatin has eight cysteines and the sequence arginine glycine aspartic acid (RGD).

Application

Echistatin from Echis carinatus has been used in diabetic rabbits grouping and treatment and murine iPSC (induced pluripotent stem cell) culture.

Actions biochimiques/physiologiques

Echistatin has the ability to prevent IRS-1 (insulin receptor substrate-1) phosphorylation induced by IGF-1 (insulin like growth factor-1). Echistatin α1, purified from the venom of the saw scaled viper, Echis carinatus has the capability to block platelet aggregation.
Disintegrins represent a novel family of integrin β1 and β3 inhibitor proteins isolated from viper venoms. They are low molecular-weight, cysteine-rich peptides containing the Arg-Gly-Asp (RGD) sequence. They are the most potent known inhibitors of integrin function. Disintegrins interfere with cell adhesion to the extracellular matrix, including adhesion of melanoma cells and fibroblasts to fibronectin, and are potent inhibitors of platelet aggregation.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Fengbin Lin et al.
International journal of clinical and experimental pathology, 8(11), 14294-14304 (2016-01-30)
To investigate the effect of disintegrin echistatin on integrin linked kinase (ILK) and subsequent PI3-K/Akt and ERK1/2 signaling pathways in the posterior capsule opacification (PCO) model of diabetic rabbit. 56 rabbits were injected alloxan to model diabetic. Then they accepted
Echistatin prevents posterior capsule opacification in diabetic rabbit model via integrin linked kinase signaling pathway.
Lin F, et al.
International Journal of Clinical and Experimental Pathology, 8(11), 14294-14294 (2015)
Animal Toxins: Facts and Protocols (2013)
Ozge Er et al.
Applied biochemistry and biotechnology, 187(4), 1539-1550 (2018-10-03)
Snake venoms are a natural biological source that has potential therapeutic value with various protein compounds. Disintegrins originally were discovered as a family of proteins from snake venoms composed of cysteine rich low molecular weight polypeptides. Disintegrins exhibit specific binding
Insulin-like Growth Factor Receptor Signalling (2003)
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