D0899

Diazepam

≥98% (TLC), powder, GABAA receptor ligand

• Synonyme(s) : 7-Chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one, Ro 5-2807
• Formule empirique (notation de Hill): C₁₆H₁₃ClN₂O
• Numéro CAS: 439-14-5
• Poids moléculaire : 284.74
• Numéro CE : 207-122-5
• Numéro MDL: MFCD00057323
• Code UNSPSC : 12352200
• ID de substance PubChem : 24893306
• Nomenclature NACRES : NA.77

Propriétés

• Nom du produit: Diazepam,
• Forme: powder
• Niveau de qualité: 200
• Contrôle du médicament: USDEA Schedule IV; Home Office Schedule 4.1; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
• Solubilité: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.6 mg/mL; DMF: soluble; H₂O: slightly soluble; ethanol: soluble
• Auteur: Roche
• Chaîne SMILES: CN1C(=O)CN=C(c2ccccc2)c3cc(Cl)ccc13
• InChI: 1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
• Clé InChI: AAOVKJBEBIDNHE-UHFFFAOYSA-N
• Informations sur le gène: human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879) ; rat ... Gabra1(29705) , Gabra2(29706)

Description

Application

Diazepam has been used:

• as an anxiolyte in pilocarpine protocol.[1][2]
• in multi-electrode array (MEA) technology[3]
• as a marker for human serum albumin[4]

Actions biochimiques/physiologiques

Anxiolytic; ligand for the GABA_A receptor benzodiazepine modulatory site.

Diazepam is a benzodiazepine anxiolytic agent. It serves as a prototype ligand for the GABAA receptor benzodiazepine modulatory site.

Diazepam is often used as a sedative. Its metabolism involves cytochrome P450 (CYP) 2C19 and 3A4.[5] Diazepam has immediate action upon administration.[6]

Caractéristiques et avantages

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H301 + H311,H410
• Conseils de prudence: P264 - P273 - P280 - P301 + P310 - P302 + P352 + P312 - P361 + P364
• Classification des risques: Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Aquatic Chronic 1
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves