Accéder au contenu
Merck
Toutes les photos(1)

Documents

C9993

Sigma-Aldrich

Anti-CD9 antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-BA2, Anti-BTCC-1, Anti-DRAP-27, Anti-GIG2, Anti-Growth-inhibiting gene 2 protein, Anti-Leukocyte antigen MIC3, Anti-MRP-1, Anti-Motility related protein, Anti-TSPAN29, Anti-p24 antigen

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Numéro MDL:
MFCD00164638
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen ~25 kDa

Espèces réactives

human, mouse, rat

Concentration

~1 mg/mL

Technique(s)

immunohistochemistry: 1:100-1:250
western blot: 1:500-1:1,000

Numéro d'accès UniProt

P21926

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... CD9(928)
mouse ... Cd9(12527)
rat ... Cd9(24936)

Description générale

CD9 is a glioma stem cell (GSC)-enriched protein, which belongs to tetraspanin family. It is a cell motility related molecule. The gene is located on human chromosome 12p13.31. CD9 is expressed on pre-B cells, activated T cells and Schwann cells.

Immunogène

synthetic peptide corresponding to residues 36-50 of human CD9.

Application

Anti-CD9 antibody produced in rabbit has been used in
  • immunostaining
  • identification of hypoxia-induced mesenchymal stem cells (MSC-MVs)
Anti-CD9 antibody produced in rabbit is suitable for immunohistochemistry at a working dilution of 1:100-1:250 and western blotting at a working dilution of 1:500-1:1000. It was used as a primary antibody for the immunolocalization of adhesion protein CD9 during a study to investigate the impact of adhesion proteins on skeletal myoblast differentiation.

Actions biochimiques/physiologiques

CD9 plays a major role in sperm-egg fusion in fertilization. It enhances cancer invasion and tumor growth in cervical cancer, gastric cancer and glioblastoma (GBM). CD9 is involved in cell invasion, apoptosis and resistance to chemotherapy.

Description de la cible

The CD9 protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It can modulate cell adhesion and migration. It also triggers platelet activation and aggregation. In addition, the protein appears to promote muscle cell fusion and support myotube maintenance.

Forme physique

solution in phosphate buffered saline, containing 0.02% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Vous ne trouvez pas le bon produit ?  

Essayez notre Outil de sélection de produits.

Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Surface phosphatidylserine is responsible for the internalization on microvesicles derived from hypoxia-induced human bone marrow mesenchymal stem cells into human endothelial cells
Wei X, et al.
PLoS ONE, 11(1), e0147360-e0147360 (2016)
CD9 suppresses human extravillous trophoblast invasion
Matsumoto H, et al.
Placenta, 47(1), 105-112 (2016)
Competence of in vitro cultured mouse embryonic stem cells for myogenic differentiation and fusion with myoblasts
Archacka K, et al.
Stem Cells and Development, 23(20), 2455-2468 (2014)
Karolina Archacka et al.
Stem cells and development, 23(20), 2455-2468 (2014-06-19)
Pluripotent stem cells are a potential source of various cell types for use in regenerative medicine. Despite accumulating knowledge, there is currently no efficient and reproducible protocol that does not require genetic manipulation for generation of myogenic cells from pluripotent
Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity
Giuliano CJ, et al.
Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression, 1731(1), 48-56 (2005)
Afficher tous les articles scientifiques apparentés

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique