C4743

Monoclonal Anti-Cytochrome P450 3A5 antibody produced in mouse

~2 mg/mL, clone F18 P3 B6, purified immunoglobulin, buffered aqueous solution

• Synonyme(s) : Anti-CP35, Anti-CYP3A5, Anti-P450PCN3, Anti-PCN3
• Code UNSPSC : 12352203

Propriétés

• Source biologique: mouse
• Conjugué: unconjugated
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: F18 P3 B6, monoclonal
• Forme: buffered aqueous solution
• Poids mol.: antigen ~55 kDa
• Espèces réactives: human
• Concentration: ~2 mg/mL
• Technique(s): immunohistochemistry: suitable; indirect ELISA: suitable; western blot: 0.5-1.0 μg/mL using human recombinant cytochrome P450 3A5.
• Isotype: IgG1
• Numéro d'accès UniProt: P20815
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... CYP3A5(1577)

Description

Spécificité

The antibody does not cross react with cytochrome P450 3A4 or 3A7.

Immunogène

synthetic peptide corresponding to amino acids 380-389 of human cytochrome P450 3A5.

Application

Monoclonal Anti-Cytochrome P450 3A5 antibody produced in mouse is suitable for:

• immunohistochemistry
• indirect ELISA
• western blotting at a concentration of 0.5-1.0 μg/mL using human recombinant cytochrome P450 3A5

Actions biochimiques/physiologiques

Cytochrome P450 enzymes are a super family of heme containing mono-oxygenases that in humans are involved with oxidative metabolism of xenobiotics. This metabolism is the initial step in the biotransformation and elimination of a wide variety of drugs and environmental pollutants from the body. The Cytochrome P450 3A (CYP 3A) family contains several isoforms with the CYP 3A4 isoform contributing most of the family activity and the CYP 3A5, 3A7 and 3A43 being the minor isoforms.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): nwg
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter