Sigma-Aldrich tests the solubility of Product A8423, Amiodarone hydrochloride in water at a concentration of 50 mg/ml. This requires heating at 105 °C for 10 minutes. This concentration is above the solubility maximum at room temperature. As per the chemicals encyclopedia published by the Royal Society of Chemistry 13th Ed., Entry #482, solubility at 25 °C, (g/100mL): Water (0.07), Ethanol (1.28), Methanol (9.98), Chloroform (44.51), Methylene Chloride (19.2), and Hexane (0.03).Reportedly, the solubility of the product is 10 mg/ml each in DMSO and in dimethylformamide.
A8423
Amiodarone hydrochloride
≥98% (TLC), powder, ion channel blocker
Synonyme(s) :
(2-Butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanone hydrochloride, 2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride
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125,00 €
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246,00 €
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404,00 €
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1 G
125,00 €
5 G
246,00 €
10 G
404,00 €
About This Item
Formule empirique (notation de Hill) :
C25H29I2NO3 · HCl
Numéro CAS:
Poids moléculaire :
681.77
Numéro CE :
Numéro MDL:
Code UNSPSC :
12352200
ID de substance PubChem :
Nomenclature NACRES :
NA.77
125,00 €
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Nom du produit
Amiodarone hydrochloride, ≥98%
Essai
≥98%
Forme
powder
Auteur
Wyeth
Température de stockage
2-8°C
Chaîne SMILES
C(=O)(C=1C=2C(OC1CCCC)=CC=CC2)C3=CC(I)=C(OCCN(CC)CC)C(I)=C3.Cl
InChI
1S/C25H29I2NO3.ClH/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3;/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3;1H
Clé InChI
ITPDYQOUSLNIHG-UHFFFAOYSA-N
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Application
Amiodarone hydrochloride has been used to study its interaction with cysteamine to stimulate autophagy in cultured biosensor cell lines.[1] It has also been used in larval and adult organ toxicogenomic screening to analyze the transcriptional effects of pharmaceuticals.[2]
Amiodarone hydrochloride is a non-selective ion channel blocker. Amiodarone induces an immediate influx of Ca2+ in Saccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. Amiodarone hydrochloride has also been used in a study to determine concentrations of thyroid disrupting substances in effluents from wastewater treatment plants.
Actions biochimiques/physiologiques
Non-selective ion channel blocker. Amiodarone induces an immediate influx of Ca2+ in Saccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
Caractéristiques et avantages
This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Substrats
CYP2C8/9 and CYP3A family (minor pathway) inhibitor and substrate; CYP2D6, CYP3A family, CYP2D6, CYP2A6, CYP2B6 desethyl-form inhibitor
Mention d'avertissement
Warning
Mentions de danger
Conseils de prudence
Classification des risques
Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Eye Irrit. 2 - Lact. - Repr. 2 - Skin Irrit. 2 - STOT SE 3
Organes cibles
Respiratory system
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
dust mask type N95 (US), Eyeshields, Gloves
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What is the solubility of Product A8423, Amiodarone hydrochloride, and in which solvents may it be reconstituted?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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