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Merck
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Principaux documents

A5737

Sigma-Aldrich

Cefotetan disodium

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About This Item

Formule empirique (notation de Hill):
C17H15N7Na2O8S4
Numéro CAS:
74356-00-6
Poids moléculaire :
619.58
Code UNSPSC :
51282206
Nomenclature NACRES :
NA.85

Forme

powder

Spectre d'activité de l'antibiotique

Gram-negative bacteria
Gram-positive bacteria

Mode d’action

cell wall synthesis | interferes

Température de stockage

2-8°C

InChI

1S/C17H17N7O8S4.2Na/c1-23-16(20-21-22-23)34-4-5-3-33-15-17(32-2,14(31)24(15)7(5)11(29)30)19-9(26)13-35-12(36-13)6(8(18)25)10(27)28;;/h13,15H,3-4H2,1-2H3,(H2,18,25)(H,19,26)(H,27,28)(H,29,30);;/q;2*+1/p-2/b12-6-;;/t13?,15-,17+;;/m1../s1

Clé InChI

ZQQALMSFFARWPK-GLHLDKNHSA-L

Actions biochimiques/physiologiques

Cefotetan (cefotan) is a second-generation cephalosporin that is active against some strains of β-lactamase producing bacteria. It shows anti-microbial activity against Gram-positive and Gram-negative bacteria; it is more efficacious against Gram-negative and anaerobic bacteria. Cefotetan binds to penicillin-binding proteins and disrupts the cell wall synthesis.
Cefotetan has good protein binding capacity due to its half-life of 3 to 4 hours. The presence of methylthiotetrazole (MTT) side chain helps to enhance its potential for hypoprothrombinemia and disulfiram reactions. It possesses high antimicrobial activity against gram-negative bacilli than cefoxitin.

Autres remarques

Keep container tightly closed in a dry and well-ventilated place.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Paul Suding et al.
Archives of surgery (Chicago, Ill. : 1960), 143(9), 907-911 (2008-09-17)
Anastomotic leaks following elective colorectal resections increase morbidity, mortality, and the need for additional interventions. An accurate understanding of risk factors would potentially reduce anastomotic leaks and/or allow appropriate selection of patients for diverting stomas. Prospective review of patient and
Susan T Johnson et al.
Transfusion, 47(4), 697-702 (2007-03-27)
Drug-induced immune hemolytic anemia (DIIHA) is an uncommon finding characterized by a sudden decrease in hemoglobin after treatment with the putative drug. The full range of drugs causing DIIHA and the initial serologic presentation are not fully appreciated. This work
Failure to administer cefotan: was standing order ambiguous? Tucker v. Women's Care Physicians of Louisville, CA-001929-mr(6/18/2010)-KY.
Nursing law's Regan report, 51(3), 2-2 (2010-11-26)
Kamal M F Itani et al.
American journal of surgery, 193(2), 190-194 (2007-01-24)
The type of mechanical bowel preparation (MBP) used before elective colorectal surgery remains controversial. This post hoc analysis of a prospective randomized controlled antibiotic prophylaxis trial (ertapenem vs. cefotetan) evaluated the effect of polyethylene glycol (PEG) and sodium phosphate (SP)
Wookeun Lee et al.
The Korean journal of laboratory medicine, 29(5), 448-454 (2009-11-07)
Plasmid-mediated AmpC beta-lactamases (PABLs) have been detected in the strains of Escherichia coli, Klebsiella spp., Proteus mirabilis, and Salmonella spp. PABLs may be difficult to detect and might interfere in the therapeutic and infection-control processes. Although several PABL-detection methods based
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